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Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex

Nature Neuroscience volume 11, pages 1140–1142 (2008)Cite this article

Abstract

Several synaptic depression mechanisms have been described for the hippocampus, cerebellum and neocortex in vitro, but little is known about which, if any, are engaged during experience-dependent depression (EDD). We found that EDD in the mouse barrel cortex depends on the AMPA subunit GluR1 in layers II/III and IV, but not in layer V, and that long-term depression is also GluR1 dependent in the IV-II/III, but not II/III–V, pathway.

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Figure 1: The effect of the GluR1−/− genotype on principal whisker depression in mice that were subject to single whisker experience (D1 only) for 7 d.
Figure 2: The effect of the GluR1−/− genotype on principal whisker depression in chessboard pattern deprived animals (7 d of deprivation).

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Acknowledgements

This work was supported by grants to K.F. from the Medical Research Council (UK) and the US National Institutes of Health (Conte Center).

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Authors and Affiliations

  1. Cardiff School of Biosciences, Cardiff University, Cardiff, CF10 3US, UK

    Nicholas Wright, Stanislaw Glazewski, Neil Hardingham, Keith Phillips, Eleftheria Pervolaraki & Kevin Fox

  2. School of Life Sciences, Keele University, Staffordshire, ST5 5BG, Keele, UK

    Stanislaw Glazewski

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  1. Nicholas Wright
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  2. Stanislaw Glazewski
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  3. Neil Hardingham
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  4. Keith Phillips
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  5. Eleftheria Pervolaraki
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Contributions

The in vivo recordings were conducted by N.W., S.G. and K.F., the in vitro recordings were made by N.H. and K.P. and the RT-PCR was carried out by E.P.

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Correspondence to Kevin Fox.

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Supplementary Figures 1–4, Supplementary Table 1, Supplementary Methods and Supplementary Results (PDF 2047 kb)

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Wright, N., Glazewski, S., Hardingham, N. et al. Laminar analysis of the role of GluR1 in experience-dependent and synaptic depression in barrel cortex. Nat Neurosci 11, 1140–1142 (2008). https://doi.org/10.1038/nn.2188

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