Abstract
A rigorous 'directed evolution' strategy has enabled a research group to design an RNA molecule capable of inducibly activating gene transcription, demonstrating a technique with the potential for rapid generation of other highly specialized functional RNAs.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Quantum dots: synthesis, bioapplications, and toxicity
Nanoscale Research Letters Open Access 28 August 2012
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Buskirk, A.R. et al. Engineering a ligand-dependent RNA transcriptional activator. Chem. Biol. 11, 1157–1163 (2004).
Buskirk, A.R. et al. In vivo evolution of an RNA-based transcriptional activator. Chem. Biol. 10, 533–540 (2003).
Mandal, M. & Breaker, R. Gene regulation by riboswitches. Nat. Rev. Mol. Cell Biol. 5, 451–463 (2004).
Rights and permissions
About this article
Cite this article
Eisenstein, M. Teaching an old molecule new tricks. Nat Methods 1, 6–7 (2004). https://doi.org/10.1038/nmeth1004-6
Issue Date:
DOI: https://doi.org/10.1038/nmeth1004-6
This article is cited by
-
Quantum dots: synthesis, bioapplications, and toxicity
Nanoscale Research Letters (2012)
