Using chemically assembled ubiquitylated histone H2B, researchers demonstrate that direct cross-talk results in methylation of a lysine on another histone.
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References
Chatterjee, C. et al. Auxiliary-mediated site-specific peptide ubiquitylation. Angew. Chem. Int. Ed. Engl. 46, 2814–2818 (2007).
McGinty, R.K. et al. Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation. Nature 453, 812–816 (2008).
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Kaganman, I. Talk among histones. Nat Methods 5, 662–663 (2008). https://doi.org/10.1038/nmeth0808-662b
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DOI: https://doi.org/10.1038/nmeth0808-662b