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Crowd control in the crypt

Cancer can ensue when cells do not know who they are or where they are. In the intestine, a single regulator seems to take care of both of these issues of identity.

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Figure 1: The intestinal crypt.

Debbie Maizels

Figure 2: β-catenin in crypts (cross section in inset.) β-catenin is found at the cell surface and in the nuclei at the base (arrow).

Reprinted with permission from Elsevier Science

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Booth, C., Brady, G. & Potten, C. Crowd control in the crypt. Nat Med 8, 1360–1361 (2002). https://doi.org/10.1038/nm1202-1360

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