Zinc-finger transcription factors can be engineered to target specific genes. Now this approach is applied successfully to a clinically relevant setting in mice—promotion of angiogenesis. (pages 1427–1432)
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Rebar, E.J. et al. Induction of angiogenesis in a mouse model using engineered transcription factors. Nature Med. 8, 1427–1432 (2002).
Beerli, R.R. & Barbas, C.F. III . Engineering polydactyl zinc-finger transcription factors. Nature Biotechnol. 20, 135–141 (2002).
Pabo, C.O., Peisach, E. & Grant, R.A. Design and selection of novel Cys2His2 zinc finger proteins. Annu. Rev. Biochem. 70, 313–340 (2001).
Xu, L. et al. A versatile framework for the design of ligand-dependent, transgene-specific transcription factors. Mol. Ther. 3, 262–273 (2001).
Guan, X. et al. Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc. Natl. Acad. Sci. USA 99, 13296–13301 (2002).
Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nature Med. 6, 460–463 (2000).
Beerli, R.R., Dreier, B. & Barbas III, C.F. Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl. Acad. Sci. USA 97, 1495–1500 (2000).
Pasqualini, R. & Arap, W. Vascular targeting. in Encyclopedia of Cancer, Vol. 4, 2nd edn. (ed. Bertino, J.R.), 501–507 (Academic Press, San Diego-Oxford, 2002).
Author information
Authors and Affiliations
Corresponding authors
Rights and permissions
About this article
Cite this article
Pasqualini, R., Barbas, C. & Arap, W. Vessel maneuvers: Zinc fingers promote angiogenesis. Nat Med 8, 1353–1354 (2002). https://doi.org/10.1038/nm1202-1353
Issue Date:
DOI: https://doi.org/10.1038/nm1202-1353
This article is cited by
-
Zinc-containing Mohs’ paste affects blood flow and angiogenesis suppression
DARU Journal of Pharmaceutical Sciences (2021)