Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Vessel maneuvers: Zinc fingers promote angiogenesis

Zinc-finger transcription factors can be engineered to target specific genes. Now this approach is applied successfully to a clinically relevant setting in mice—promotion of angiogenesis. (pages 1427–1432)

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Designer fingers.

Kimberly Homer

References

  1. Rebar, E.J. et al. Induction of angiogenesis in a mouse model using engineered transcription factors. Nature Med. 8, 1427–1432 (2002).

    Article  CAS  Google Scholar 

  2. Beerli, R.R. & Barbas, C.F. III . Engineering polydactyl zinc-finger transcription factors. Nature Biotechnol. 20, 135–141 (2002).

    Article  CAS  Google Scholar 

  3. Pabo, C.O., Peisach, E. & Grant, R.A. Design and selection of novel Cys2His2 zinc finger proteins. Annu. Rev. Biochem. 70, 313–340 (2001).

    Article  CAS  Google Scholar 

  4. Xu, L. et al. A versatile framework for the design of ligand-dependent, transgene-specific transcription factors. Mol. Ther. 3, 262–273 (2001).

    Article  CAS  Google Scholar 

  5. Guan, X. et al. Heritable endogenous gene regulation in plants with designed polydactyl zinc finger transcription factors. Proc. Natl. Acad. Sci. USA 99, 13296–13301 (2002).

    Article  CAS  Google Scholar 

  6. Thurston, G. et al. Angiopoietin-1 protects the adult vasculature against plasma leakage. Nature Med. 6, 460–463 (2000).

    Article  CAS  Google Scholar 

  7. Beerli, R.R., Dreier, B. & Barbas III, C.F. Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl. Acad. Sci. USA 97, 1495–1500 (2000).

    Article  CAS  Google Scholar 

  8. Pasqualini, R. & Arap, W. Vascular targeting. in Encyclopedia of Cancer, Vol. 4, 2nd edn. (ed. Bertino, J.R.), 501–507 (Academic Press, San Diego-Oxford, 2002).

    Chapter  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Renata Pasqualini or Carlos F. Barbas III.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pasqualini, R., Barbas, C. & Arap, W. Vessel maneuvers: Zinc fingers promote angiogenesis. Nat Med 8, 1353–1354 (2002). https://doi.org/10.1038/nm1202-1353

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1202-1353

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing