Studies on patients with sickle-cell disease now shed light on the physiological battle between hemoglobin and the vasoregulator nitric oxide. It appears that hemoglobin scavenges NO in these patients, likely contributing to vascular complications (pages 1383–1389).
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References
Liu, X. et al. Diffusion-limited reaction of free nitric oxide with erythrocytes. J. Biol. Chem. 273, 18709–18713 (1998).
Liao, J.C., Hein, T.W., Vaughn, M.W., Huang, K.T. & Kuo, L. Intravascular flow decreases erythrocyte consumption of nitric oxide. Proc. Natl. Acad. Sci. USA 96, 8757–8761 (1999).
Huang, K.T. et al. Modulation of nitric oxide bioavailability by erythrocytes. Proc. Natl. Acad. Sci. USA. 98, 11771–11776 (2001).
Gow, A.J., Luchsinger, B.P., Pawloski, J.R, Singel, D.J. & Stamler, J.S. The oxyhemoglobin reaction of nitric oxide. Proc. Natl. Acad. Sci. USA 96, 9027–9032 (1999).
McMahon, T.J. et al. Nitric oxide in the human respiratory cycle. Nature Med. 8, 711–717 (2002).
Reiter, et al. Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nature Med. 8, 1383–1389 (2002).
Aslan, M. et al. Oxygen radical inhibition of nitric oxide-dependent vascular function in sickle cell disease. Proc. Natl. Acad. Sci. USA 98, 15215–15220 (2001).
Gladwin, M.T. et al. Relative role of heme nitrosylation and β-cysteine 93 nitrosation in the transport and metabolism of nitric oxide by hemoglobin in the human circulation. Proc. Natl. Acad. Sci. USA 97, 9943–9948 (2000).
Doherty, D.H. et al. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin. Nature Biotechnol. 16, 672–676 (1998).
Sloan, E.P. et al. Daspirin cross-linked hemoglobin (DCLHemoglobin) in the treatment of severe traumatic hemorrhagic shock: A randomized controlled efficacy trial. JAMA 282, 1857–1864 (1999).
Carlsen, E. & Comroe, J.H. The rate of uptake of carbon monoxide and nitric oxide by normal human erythrocytes and experimentally produced spherocytes. J. Gen. Physiol. 42, 83–107 (1958).
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Liao, J. Blood feud: Keeping hemoglobin from nixing NO. Nat Med 8, 1350–1351 (2002). https://doi.org/10.1038/nm1202-1350
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DOI: https://doi.org/10.1038/nm1202-1350
