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Inflammatory thoughts about glioma gene therapy

Nature Medicine volume 5, pages 1237–1238 (1999)Cite this article

Abstract

Gene therapy for treatment of glioma often involves delivery of herpes simplex virus-1 thymidine kinase gene. A new study shows that this approach can induce chronic inflammation, and raises important questions about current adenoviral-based clinical trials (pages 1256–1263).

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Authors and Affiliations

  1. Department of Pathology Dartmouth Medical School Dartmouth Hitchcock Medical Center, Lebanon, 03756, New Hampshire, USA

    Tammy Kielian & William F. Hickey

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  1. Tammy Kielian
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  2. William F. Hickey
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Kielian, T., Hickey, W. Inflammatory thoughts about glioma gene therapy. Nat Med 5, 1237–1238 (1999). https://doi.org/10.1038/15188

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