Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

The end replication problem: More than one solution

Nature Medicine volume 3, pages 1198–1199 (1997)Cite this article

The connection between telomerase and oncogenesis may be more complex than initially thought (pages 1271–1274).

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Greider, C.W. & Blackburn, E.H. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 43, 405–413 (1985).

    Article  CAS  Google Scholar 

  2. Lingner, J. et al. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276, 561–567 (1997).

    Article  CAS  Google Scholar 

  3. Counter, C.M., Meyerson, M., Eaton, E.N. & Weinberg, R.A. The catalytic subunit of yeast telomerase. Proc. Natl. Acad. Sci. USA 94, 9202–9207 (1997).

    Article  CAS  Google Scholar 

  4. Nakamura, T.M. et al. Telomerase catalytic subunit homologs from fission yeast and human. Science 277, 955–959 (1997).

    Article  CAS  Google Scholar 

  5. Meyerson, M. et al. hEST2 the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization. Cell 90, 785–795 (1997).

    Article  CAS  Google Scholar 

  6. Harley, C.B. Telomere loss: Mitotic clock or genetic time bomb? Mut Res. 256, 271–282 (1991).

    Article  CAS  Google Scholar 

  7. Shay, J.W., Bacchetti, S. A survey of telomerase activity in human cancer. European Journal of Cancer 33, 787–791 (1997).

    Article  CAS  Google Scholar 

  8. Bryan, T.M., Englezou, A., Dalla-Pozza, L., Dunham, M.A. & Reddel, R.R. Evidence for an alternative mechanism for lengthening telomeres in human tumors and tumor-derived cell lines. Nature Med. 3, 1271–1274 (1997).

    Article  CAS  Google Scholar 

  9. Lundblad, V. & Blackburn, E.H. An alternative pathway for yeast telomere maintenance rescues est7− senescence. Cell 73, 347–360 (1993).

    Article  CAS  Google Scholar 

  10. McEachem M.J. & Blackburn, E.H. Cap-prevented recombination between terminal tetomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev. 10, 1822–1834 (1996).

    Article  Google Scholar 

  11. Pardue, M.L., Danilevskaya, O.N., Lowenhaupt, K., Slot, F. & Traverse, K.L. Drosophila telomeres: new views on chromosome evolution. Trends Genet 12, 48–52 (1996).

    Article  CAS  Google Scholar 

  12. Blasco, M.A. et al. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91, 25–34 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Human Genetics Baylor College of Medicine, Houston, Texas, 77030, USA

    Victoria Lundblad

Authors
  1. Victoria Lundblad
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lundblad, V. The end replication problem: More than one solution. Nat Med 3, 1198–1199 (1997). https://doi.org/10.1038/nm1197-1198

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm1197-1198

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing