Virologists and immunologists are all too aware of the ability of HIV to evade efforts by its human host to destroy it within the body. Now, two new pieces of evidence reveal yet more of HIV's survival abilities: the virus uses a single protein both to trigger and block apoptosis as the situation demands. (pages 1217–1224)
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References
Wolf, D. et al. Nef-associated PAK and PI3-kinases stimulate Bad phosphorylation in an Akt-independent pathway. Implications for anti-apoptosis signaling in HIV-infected cells. Nature Med. 7, 1217–1224 (2001).
Geleziunas, R., Xu, W., Takeda, K., Ichijo, H. & Greene, W.C. HIV-1 Nef inhibits ASK1-dependent death signalling providing a potential mechanism for protecting the infected host cell. Nature 410, 834–838 (2001).
Badley, A.D., Pilon, A.A., Landay, A. & Lynch, D.H. Mechanisms of HIV-associated lymphocyte apoptosis. Blood 96, 2951–2964 (2000).
Zauli, G. et al. Human immunodeficiency virus type 1 Nef protein sensitizes CD4(+) T lymphoid cells to apoptosis via functional upregulation of the CD95/CD95 ligand pathway. Blood 93, 1000–1010 (1999).
Xu, X.N. et al. Induction of Fas ligand expression by HIV involves the interaction of Nef with the T cell receptor ζ chain. J. Exp. Med. 189, 1489–1496 (1999).
Xu, X.N. et al. Evasion of CTL responses by Nef-dependent induction of Fas ligand on SIV-infectecd cells. J. Exp. Med. 186, 7–16 (1997).
Kestler, H.W. et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651–662 (1991).
Piguet, V. et al. The dowregulation of CD4 and MHC-1 by primate lentiviruses: A paradigm for the modulation of cell surface receptors. Immunol. Rev. 168, 51–63 (1999).
Gross, A., McDonnell, J.M. & Korsmeyer, S.J. Bcl-2 family members and the mitochondria in apoptosis. Genes Dev. 13, 1899–1911 (1999).
Savill, J. & Fadok, V. Corpse clearance defines the meaning of cell death. Nature 407, 784–788 (2000).
Kennedy, N.J., Kataoka, T., Tschopp, J. & Budd, R.C. Caspase activation is required for T cell proliferation. J. Exp. Med. 190, 1891–1896 (1999).
Baba, T.W. et al. Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267, 1820–1825 (1995).
Lang, S.M. et al. Association of SIV Nef with cellular serine/threonine kinases is dispensable for the development of AIDS in rhesus macaques. Nature Med. 3, 860–865 (1997).
Khan, I.H. et al. Role of the SH3-ligand domain of SIV Nef in interaction with Nef-associated kinase and simian AIDS in rhesus macaques. J. Virol. 72, 5820–5830 (1998).
Chakrabarti, L.A. et al. Normal T-cell turnover in sooty mangabeys harboring active simian immunodeficiency virus infection. J. Virol. 74, 1209–1223 (2000).
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Claude Ameisen, J. Apoptosis subversion: HIV-Nef provides both armor and sword. Nat Med 7, 1181–1182 (2001). https://doi.org/10.1038/nm1101-1181
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DOI: https://doi.org/10.1038/nm1101-1181
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