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To be or notch to be

Nature Medicine volume 6, pages 1210–1211 (2000)Cite this article

Constitutive activation of Notch signaling in hematopoietic cells establishes an immortalized hematopoietic stem cell population capable of developing into both myeloid and lymphoid lineages. This system will be useful in determining Notch-mediated mechanisms of hematopoietic differentiation (pages 1278–1281).

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Figure 1: The influence of Notch1 activation on stem cell self-renewal and on the fate of stem cell progeny, as demonstrated by events in the T-cell pathway.

Bob Crimi

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  1. Center for Cell and Gene Therapy, Baylor College of Medicine, 6621 Fannin St., Houston, 77030, Texas

    Malcolm Brenner

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  1. Malcolm Brenner
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Brenner, M. To be or notch to be. Nat Med 6, 1210–1211 (2000). https://doi.org/10.1038/81297

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