Abstract
A calcium-binding protein interacts with the presenilins, modulating their proteolytic processing (pages 1177–1181).
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References
Selkoe, D.J. Amyloid-ß protein and the genetics of Alzheimer's disease. J. Biol. Chem. 271, 18295–18298 (1996).
Blacker, D. et al. Alpha-2-macroglobulin is genetically associated with Alzheimer's disease. Nature Genet. 19, 357– 360 (1998).
Tanzi, R.E. The molecular genetics of Alzheimer's disease. In Scientific American: Molecular Neurology (ed. J. B. Martin) 55–75 (Scientific American, New York, 1998).
Buxbaum, J. et al. Calsenilin: A novel calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment. Nature Med. 4, 1177–1181 (1998).
Price, D.L. & Sisodia, S.S. Mutant genes in familial Alzheimer's disease and transgenic models. Annu. Rev. Neurosci. 21, 479–505 (1998).
Cotman, C.W. & Anderson, A.J. A potential role for apoptosis in neurodegeneration and Alzheimer's disease. Molec. Neurobiol . 10, 19–27 ( 1995).
Vito, P. et al. Requirement of the familial Alzheimer's disease gene PS2 in apoptosis. J. Biol. Chem. 49, 31025– 31028 (1996).
Wolozin, B. et al. Participation of presenilin 2 in apoptosis: Enhanced basal activity conferred by an Alzheimer mutation. Science 274, 1710–1713 (1996).
Keller, J. et al. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production. J. Neurosci. 18, 4439–4450 (1998).
Kim, T-W., Pettingell, W.H., Jung, Y.K., Kovacs, D.M. & Tanzi, R.E. Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease. Science 277, 373–376 ( 1997).
Roperch, J.-P. et al. Inhibition of presenilin-1 expression is promoted by p53 and p21WAF-1 and results in apoptosis and tumor suppression. Nature Med. 4, 835–839 ( 1998).
Querforth, H.W. & Selkoe D.J. Calcium ionophore increases amyloid-ß peptide production by cultured cells. Biochemistry 33, 4550–4561 (1994).
Kim, T.-W., Pettingell, W.P. & Tanzi, R.E. Identification of sorcin as a selective cellular interactor for presenilin 2. Soc. Neurosci. Abstr. 24, 757 (1998).
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Tanzi, R. Of calcium, caspases, and cognitive decline. Nat Med 4, 1127–1128 (1998). https://doi.org/10.1038/2622
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DOI: https://doi.org/10.1038/2622
