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Getting to the core of atherosclerosis

Nature Medicine volume 14, pages 1015–1016 (2008)Cite this article

For years, researchers have debated whether the enzyme lipoprotein-associated phospholipase A2 (Lp-PLA2), produced by inflammatory cells, is a 'good guy' or 'bad guy' in atherosclerosis. Work in pigs provides strong support for the view that Lp-PLA2 promotes the formation of atherosclerotic lesions and dangerous, unstable atherosclerotic plaques (pages 1059–1066).

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Figure 1: A selective inhibitor of Lp-PLA2 targets atherosclerotic plaques.

References

  1. Glass, C.K. & Witztum, J.L. Cell 104, 503–516 (2001).

    Article  PubMed  Google Scholar 

  2. Tabas, I., Williams, K.J. & Boren, J. Circulation 116, 1832–1844 (2007).

    Article  PubMed  Google Scholar 

  3. Shah, P.K. Curr. Opin. Lipidol. 18, 492–499 (2007).

    Article  PubMed  Google Scholar 

  4. Wilensky, R.L. et al. Nat. Med. 14, 1059–1066 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Kolodgie, F.D. et al. Arterioscler. Thromb. Vasc. Biol. 26, 2523–2529 (2006).

    Article  PubMed  Google Scholar 

  6. Packard, C.J. et al. N. Engl. J. Med. 343, 1148–1155 (2000).

    Article  PubMed  Google Scholar 

  7. Garza, C.A. et al. Mayo Clin. Proc. 82, 159–165 (2007).

    Article  PubMed  Google Scholar 

  8. Stafforini, D.M., Prescott, S.M. & McIntyre, T.M. J. Biol. Chem. 262, 4223–4230 (1987).

    PubMed  Google Scholar 

  9. Tjoelker, L.W. et al. Nature 374, 549–553 (1995).

    Article  PubMed  Google Scholar 

  10. Zalewski, A. & Macphee, C. Arterioscler. Thromb. Vasc. Biol. 25, 923–931 (2005).

    Article  PubMed  Google Scholar 

  11. Gardner, A.A., Reichert, E.C., Topham, M.K. & Stafforini, D.M. J. Biol. Chem. 283, 17099–17106 (2008).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Mohler, E.R. III et al. J. Am. Coll. Cardiol. 51, 1632–1641 (2008).

    Article  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Nancy R. Webb is in the University of Kentucky Department of Medicine, Cardiovascular Research Center, 535 Wethington Building, 900 South Limestone, Lexington, Kentucky 40536-0200, USA. nrwebb1@uky.edu,

    Nancy R Webb

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  1. Nancy R Webb
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Webb, N. Getting to the core of atherosclerosis. Nat Med 14, 1015–1016 (2008). https://doi.org/10.1038/nm1008-1015

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