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Mutants escape from killer T cells, invade population

Nature Medicine volume 9, pages 1254–1255 (2003)Cite this article

A frenzied bout of evolution occurs every flu season, as viruses test the limits of the human immune system. Variants that can evade attack by cytotoxic T cells gain a firm foothold in the viral population even if they confer an advantage in a low percentage of human hosts. A new mathematical model examines this unusual dynamic.

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Figure 1: Gog et al. present a mathematical model for the dynamics of influenza infection and viral escape from an HLA-B27-restricted CTL response.

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  1. Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, MP-665, Seattle, 98019, Washington, USA

    Dominik Wodarz

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  1. Dominik Wodarz
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Wodarz, D. Mutants escape from killer T cells, invade population. Nat Med 9, 1254–1255 (2003). https://doi.org/10.1038/nm1003-1254

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