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Induction of an oncogenic fusion protein by a viral gene—a new chapter in an old story

Abstract

A combination of 19th century cytology and 20th century molecular biology has uncovered a previously unknown mechanism by which viruses may contribute to carcinogenesis (pages 1076–1079).

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Figure 1: Two pathways by which DNA viruses can can transform normal cells into cancer cells.

References

  1. Barker, D.D. & Berk, A.J. Adenovirus proteins from both E1B reading frames are required for transformation of rodent cells by viral infection and DNA transfection. Virology 156, 107– 121 (1987).

    Article  CAS  Google Scholar 

  2. Whyte, P., Williamson, N. & Harlow, E. Cellular targets for transformation by the adenovirus E1A proteins. Cell 56, 67– 75 (1989).

    Article  CAS  Google Scholar 

  3. Chiou, S.K., Tseng, C.C., Rao, L. & White, E. Functional complementation of the adenovirus E1B 19-kilodalton protein with Bcl-2 in the inhibition of apoptosis in infected cells. J. Virol. 68, 6553–6566 (1994).

    CAS  PubMed  PubMed Central  Google Scholar 

  4. Sanchez-Prieto, R. et al. A novel association between viral genes and human oncogenic alterations: The adenovirus E!A induces the Ewing's tumor fusion transcript EWS/FL11. Nature Med., 5 1076– 1079 (1999).

    Article  CAS  Google Scholar 

  5. May, W.A. Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation. Proc. Natl. Acad. Sci. USA 90, 5752– 5756 (1993).

    Article  CAS  Google Scholar 

  6. Shenk, T. in Fields Virology (eds. Fields, B.N., Knipe, D.M. & Howley, P.M.) 2135–2137 (Lippincott Williams & Wilkins Publishers, Raven, Philadelphia, 1996).

    Google Scholar 

  7. Ginsberg, H.S. & Young, C.S. Genetics of adenoviruses. Adv. Cancer Res. 23, 91–130 (1976).

    Article  CAS  Google Scholar 

  8. Green, M. in Cold Spring Harbor Laboratory (eds. Essex, M., Todaro, G. & zurHausen, H.) 373–397 (Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, 1980).

    Google Scholar 

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Kirn, D., Hermiston, T. Induction of an oncogenic fusion protein by a viral gene—a new chapter in an old story. Nat Med 5, 991–992 (1999). https://doi.org/10.1038/12426

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