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HIV-1 Nef protein: An invitation to a kill

Abstract

New evidence demonstrates that HIV-1 Nef production by macrophages not only attracts T-lymphocytes but also renders them permissive for HIV-1 infection (pages 997–1003).

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Figure 1: Nef promotes the spread of HIV-1 from infected macrophages.

References

  1. Cullen, B.R. HIV-1 auxiliary proteins: Making connections in a dying cell. Cell 93, 685–692 ( 1998).

    Article  CAS  Google Scholar 

  2. Kestler, H.W. III et al. Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65, 651–662 ( 1991).

    Article  CAS  Google Scholar 

  3. Swingler, S. et al. HIV-1 Nef mediates lymphocyte chemotaxis and activation by infected macrophages. Nature Med. 5, 997 –1003 (1999).

    Article  CAS  Google Scholar 

  4. Lama, J. et al. Cell-surface expression of CD4 reduces HIV-1 infectivity by blocking Env incorporation in a Nef- and Vpu-inhibitable manner. Curr. Biol. 9, 622–631 ( 1999).

    Article  CAS  Google Scholar 

  5. Ross, T.M. et al. Inhibition of HIV-1 progeny virion release by cell-surface CD4 is relieved by expression of the viral Nef protein. Curr. Biol. 9, 613–621 ( 1999).

    Article  CAS  Google Scholar 

  6. Collins, K. L. et al. HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature 391, 397–401 (1998).

    Article  CAS  Google Scholar 

  7. Du, Z. et al. Identification of a nef allele that causes lymphocyte activation and acute disease in macaque monkeys. Cell 82, 665–674 (1995).

    Article  CAS  Google Scholar 

  8. Alexander, L. et al. A role for natural simian immunodeficiency virus and human immunodeficiency virus type 1 Nef alleles in lymphocyte activation. J. Virol. 71, 6094–6099 (1997).

    CAS  Google Scholar 

  9. Baur, A.S. et al. HIV-1 Nef leads to inhibition or activation of T cells depending on its intracellular localization. Immunity 1, 373–384 (1994).

    Article  CAS  Google Scholar 

  10. Skowronski, J. et al. Altered T cell activation and development in transgenic mice expressing the HIV-1 nef gene. EMBO J. 12, 703–713 (1993).

    Article  CAS  Google Scholar 

  11. Saksela, K. et al. Proline-rich (PxxP) motifs in HIV-1 Nef bind to SH3 domains of a subset of Src kinases and are required for the enhanced growth of Nef+ viruses but not for down-regulation of CD4. EMBO J. 14, 484–491 (1995).

    Article  CAS  Google Scholar 

  12. Fackler, O.T. et al. Activation of Vav by Nef induces cytoskeletal rearrangements and downstream effector functions. Mol. Cell 3, 729–739 (1999).

    Article  CAS  Google Scholar 

  13. Zhu, T. et al. Genotypic and phenotypic characterization of HIV-1 in patients with primary infection. Science 261, 1179 –1181 (1993).

    Article  CAS  Google Scholar 

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Cullen, B. HIV-1 Nef protein: An invitation to a kill. Nat Med 5, 985–986 (1999). https://doi.org/10.1038/12417

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