As knowledge about the importance of the p53 protein grows, so do the number of potential options for successful treatment of cancer.
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References
Lee, S., Elenbaas, B., Levine, A. & Griffith, J. p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell 81, 1013–1020 (1995).
Jayaraman, L. & Prives, C. Activation of p53 sequence-specific DNA binding by short single strands of DNA requires the p53 C-terminus. Cell 81, 1021–1029 (1995).
Molinari, M. & Milner, J. p53 in complex with DNA is resistant to ubiquitin-dependent proteolysis in the presence of HPV-16 E6. Oncogene 10, 1849–1854 (1995).
Cho, Y., Gorina, S., Jeffrey, P.D. & Pavletich, N.P. Crystal structure of a p53 tumor suppressor-DNA complex: Understanding tumourigenic mutations. Science 265, 346–355 (1994).
Rolley, N., Butcher, S. & Milner, J. Specific DNA binding by different classes of human p53 mutants. Oncogene (in the press).
Crawford, L.V., Pim, D. & Lamb, P. The cellular protein p53 in human tumours. Molec. biol. Med. 2, 261–272 (1984).
Medcalf, E.A. & Milner, J. Targeting and degradation of p53 by E6 of human papilloma virus type 16 is preferential for the 1620+ p53 conformation. Oncogene 8, 2847–2851.
Wang, Y. & Prives, C. Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases. Nature 376, 88–l91 (1995).
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Milner, J. DNA damage, p53 and anticancer therapies. Nat Med 1, 879–880 (1995). https://doi.org/10.1038/nm0995-879
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DOI: https://doi.org/10.1038/nm0995-879
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