Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A suicide note from Alzheimer disease neurons?

Nature Medicine volume 4, pages 897–898 (1998)Cite this article

New findings implicate apoptosis in the death of neurons in Alzheimer disease but the evidence is still insufficient to formally indict apoptosis in the neurodegeneration associated with this disease (pages 957–962).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Guo, Q. et al. Par-4 is a novel mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease. Nature Med. 4, 957–962 (1998).

    Article  CAS  Google Scholar 

  2. Cotman, C.W. & Su, J.H. Mechanisms of neuronal death in Alzheimer's disease. Brain Pathol. 6, 493–506 (1996).

    Article  CAS  Google Scholar 

  3. Tsang, S.Y., Tam, S.C., Bremner, I. & Burkitt, M.J. Copper-1,10-phenanthroline induces internucleosomal DNA fragmentation in HepG2 cells, resulting from direct oxidation by the hydroxyl radical. Biochem. J. 317, 13–16 (1996).

    Article  CAS  Google Scholar 

  4. Stadelmann, C., Brück, W., Bancher, C., Jellinger, K. & Lassmann, H. Alzheimer disease: DNA fragmentation indicates increased neuronal vulnerability, but not apoptosis. J. Neuropathol. Exp. Neural. 57, 456–464 (1998).

    Article  CAS  Google Scholar 

  5. Su, J.H., Deng, G. & Cotman, C.W. Neuronal DNA damage precedes tangle formation and is associated with up-regulation of nitrotyrosine in Alzheimer's disease brain. Brain Res. 774, 193–199 (1997).

    Article  CAS  Google Scholar 

  6. Smith, M.A. et al. Oxidative damage in Alzheimer's disease. Nature 382, 120–121 (1996).

    Article  CAS  Google Scholar 

  7. Irizarry, M.C., McNamara, M., Fedorchak, K., Hsiao, K. & Hyman, B.T. APPSw trangenic mice develop age-related Aβ deposits and neuropil abnormalities, but no neuronal loss in CA1. J. Neuropathol. Exp. Neural. 56, 965–973 (1997).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Pathology, Case Western Reserve University, Cleveland, Ohio, 44106, USA

    George Perry, Akihiko Nunomura & Mark A. Smith

Authors
  1. George Perry
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Akihiko Nunomura
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Mark A. Smith
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Perry, G., Nunomura, A. & Smith, M. A suicide note from Alzheimer disease neurons?. Nat Med 4, 897–898 (1998). https://doi.org/10.1038/nm0898-897

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0898-897

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing