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Lessons from an age-old war

Studying the mechanisms by which pathogens evade the immune response may lead to new therapeutic strategies (pages 939–944).

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References

  1. Sharipo, A., Imreh, M., Leochiks, A., Imreh, S. & Masucci, M.G. A minimal Gly-Ala repeat prevents the interaction of ubiquinated IκBα with the proteasome: A new mechanism for selective inhibition of proteolysis. Nature Med. 4, 939–944 (1998).

    Article  CAS  Google Scholar 

  2. Coux, O., Tanaka, K. & Goldberg, A.L. Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 265, 801–847 (1996).

    Article  Google Scholar 

  3. Masucci, M.G. & Ernberg, I. Adaptation to a life within the immune system. Trends Microbiol. 2, 125–130 (1994).

    Article  CAS  Google Scholar 

  4. Steven, N.M. Epstein-Barr virus latent infection in vivo. Rev. Med. Virol. 7, 97–106 (1997).

    Article  CAS  Google Scholar 

  5. Levitskaya, J. et al. Inhibition of antigen processing by the internal repeat region of the Epstein-Barr virus nuclear antigen-1. Nature 375, 685–688 (1995).

    Article  CAS  Google Scholar 

  6. Levitskaya, J., Sharipo, A., Leonchiks, A., Ciechanover, A. & Masucci, M.G. Inhibition of ubiquitin/protea-some-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc. Natl. Acad. Sci. USA 94, 12616–12621 (1997).

    Article  CAS  Google Scholar 

  7. Barnes, P.J. & Karin, M. Nuclear factor κB—a pivotal transcription factor in chronic inflammatory disease. New. Eng. J. Med. 336, 1066–1071 (1997).

    Article  CAS  Google Scholar 

  8. Bach, F.H. et al. Modification of vascular responses in xenotransplantation: Inflammation and apoptosis. Nature Med. 3, 944–948 (1997).

    Article  CAS  Google Scholar 

  9. Beg, A.A. & Baltimore, D. An essential role for NF-kappa B in preventing TNF-alpha-induced cell death. Science 274, 782–784 (1996).

    Article  CAS  Google Scholar 

  10. Wang, C.Y., Mayo, M.W. & Baldwin, A.S., Jr. TNF-and cancer therapy-induced apoptosis: Potentiation by inhibition of NF-kappa B. Science 274, 784–787 (1996).

    Article  CAS  Google Scholar 

  11. Van Antwerp, D.J., Martin, S.J., Kafri, T., Green, D.R. & Verma, I.M. Suppression of TNF-alpha-induced apoptosis by NF-kappa B. Science 274, 787–789 (1996).

    Article  CAS  Google Scholar 

  12. Riddell, S.R. & Greenberg, P.D. T cell therapy of human CMV and EBV infection in immunocompro-mised hosts. Rev. Med. Virol. 7, 181–192 (1997).

    Article  CAS  Google Scholar 

  13. Karre, K. & Welsh, R.M. Viral decoy vetoes killer cell. Nature 386, 446–447 (1997).

    Article  CAS  Google Scholar 

  14. Wiertz, E.J., Mukherjee, S. & Ploegh, H.L. Viruses use stealth technology to escape from the host immune system. Mol. Med. Today 3, 116–123 (1997).

    Article  CAS  Google Scholar 

  15. Oldstone, M.B. How viruses escape from cytotoxic T lymphocytes: Molecular parameters and players. Virology 234, 179–185 (1997).

    Article  CAS  Google Scholar 

  16. McMichael, A. T cell responses and viral escape. Cell 93, 673–676 (1998).

    Article  CAS  Google Scholar 

Download references

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Powis, S. Lessons from an age-old war. Nat Med 4, 887–888 (1998). https://doi.org/10.1038/nm0898-887

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