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Coaxing coagulation with RNA and cell fragments

Nature Medicine volume 9, pages 991–992 (2003)Cite this article

Two new therapeutic strategies show promise in mouse models of hemophilia. One uses an RNA repair approach relying on trans-splicing to patch a genetic defect in a mouse model. Another aims at microparticles, cell fragments that seem to promote coagulation (pages 1015–1019 and 1020–1025).

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Figure 1: The coagulation cascade.
Figure 2: RNA repair by spliceosome-mediated RNA trans-splicing.

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  1. Howard Hughes Medical Institute, Children's Hospital of Philadelphia, Abramson Bldg. 310, 3615 Civic Center Blvd, Philadelphia, 19104, Pennsylvania, USA

    Katherine A High

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  1. Katherine A High
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High, K. Coaxing coagulation with RNA and cell fragments. Nat Med 9, 991–992 (2003). https://doi.org/10.1038/nm0803-991

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