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Targeting AIDS-Kaposi's sarcoma

Nature Medicine volume 5, pages 738–739 (1999)Cite this article

Abstract

A new in vivo study shows that an interleukin-4–Pseudomonas aeruginosa hybrid immunotoxin efficiently eradicates AIDS-KS xenografts in nude mice and prevents tumor-associated symptoms (pages 817–822).

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Figure 1: Mechanism of cell killing by Pseudomonas exotoxin and derived immunotoxins.
Figure 2: Circularly permuted IL-4 PE immunotoxin.

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Authors and Affiliations

  1. Division of Hematology-Oncology, Department of Medicine and Center for Lymphoma and Myeloma, Laboratory of Viral Oncogenesis, Weill Medical College of Cornell University, 1300 York Avenue C-632, New York, 10021, New York, USA

    Enrique A. Mesri

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  1. Enrique A. Mesri
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Mesri, E. Targeting AIDS-Kaposi's sarcoma. Nat Med 5, 738–739 (1999). https://doi.org/10.1038/10459

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