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Full speed ahead for tumor screening

A new high-throughput tissue microarray technology is capable of simultaneously testing hundreds of tumor samples for a number of different molecular markers (pages 848–847).

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References

  1. Tlsty, T.D., Margolin, B.H. & Lum, K. Differences in the rates of gene amplification in nontumori-genie and tumorigenic cell lines as measured by Luria-Delbruck fluctuation analysis. Proc. Natl. Acad. Sci. U. S. A. 86, 9441–9445 (1989).

    Article  CAS  Google Scholar 

  2. Forozan, F., Karhu, R., Kononen, J., Kallioniemi, A. & Kallioniemi, O.P. Genome screening by comparative genomic hybridization. Trends. Genet. 13, 405–409 (1997).

    Article  CAS  Google Scholar 

  3. Courjal, F. & Theillet, C. Comparative genomic hybridization analysis of breast tumors with predetermined profiles of DNA amplification. Cancer Res. 57, 4368–4377 (1997).

    CAS  PubMed  Google Scholar 

  4. Kononen, J. et al. Tissue microarrays for high throughput molecular profiling of hundreds of tumor specimens. Nature Med. 4, 844–847 (1998).

    Article  CAS  Google Scholar 

  5. Allred, D.C., Harvey, J.M., Berardo, M. & Clark, G.M. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod. Pathol. 11, 155–168 (1998).

    CAS  PubMed  Google Scholar 

  6. De Risi, J. et al. Use of a cDNA microarray to analyse gene expression patterns in human cancer. Nature Genet. 14, 457–460 (1996).

    Article  CAS  Google Scholar 

  7. Strausberg, R.L. Genetics in profile. Conference on genetic profiling and diagnostics, San Diego, California, USA, 29–30 October, 1997. Trends. Genet. 14, 50–51 (1998).

    Google Scholar 

  8. Nelson, P.S. et al. An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones. Genomics 47, 12–25 (1998).

    Article  CAS  Google Scholar 

  9. Nelson, P.S. et al. Hevin, an antiadhesive extracellular matrix protein, is downregulated in metastatic prostate adenocarcinoma. Cancer Res. 58, 232–236 (1998).

    CAS  PubMed  Google Scholar 

  10. Dib, C. et al. A comprehensive genetic map of the human genome based on 5264 microsatellites. Nature 380, 152–154 (1996).

    Article  CAS  Google Scholar 

  11. Courjal, F. et al. Mapping of DNA amplifications at 15 chromosomal localizations in 1875 breast tumors: definition of phenotypic groups. Cancer Res. 57, 4360–4367 (1997).

    CAS  PubMed  Google Scholar 

Download references

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Theillet, C. Full speed ahead for tumor screening. Nat Med 4, 767–768 (1998). https://doi.org/10.1038/nm0798-767

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