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Keeping up with the Cajal rhythm

Nature Medicine volume 4, pages 765–767 (1998)Cite this article

New evidence shows that the interstitial cells of Cajal are the intestinal pacemaker cells that regulate gut motility (pages 848–851).

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References

  1. Thomsen, L. et al. Interstitial cells of Cajal generate a rhythmic pacemaker current. Nature Med. 4, 848–851 (1998).

    Article  CAS  PubMed  Google Scholar 

  2. Cajal, R.-Y. Sur les ganglions et plexus de l'intestin. Compt. Rend. Soc. Biol. (Paris) 45, 217–223 (1893).

    Google Scholar 

  3. Thuneberg, L. Interstitial cells of Cajal: intestinal pacemaker cells. Adv. Anat. Embryol. Cell Biol. 71, 1–130 (1982).

    Article  CAS  PubMed  Google Scholar 

  4. Maeda, H. et al. Requirement of c-kit for development of intestinal pacemaker system. Development 116, 369–375 (1992).

    CAS  PubMed  Google Scholar 

  5. Vanderwinden, J.M., Liu, H., DeLaet, M.H. & Vanderhaeghen, J.J. Study of the interstitial cells of Cajal in infantile hypertrophic pyloric stenosis. Gastroenterology 111, 279–288 (1996a).

    Article  CAS  PubMed  Google Scholar 

  6. Vanderwinden, J.M. et al. Interstitial cells of Cajal in human colon and in Hirschsrung's disease. Gastroenterology 111, 901–910 (1996b).

    Article  CAS  PubMed  Google Scholar 

  7. Isozaki, K. et al. Deficiency of c-kit+ cells in patients with a myopathic form of chronic idiopathic intestinal pseudo-obstruction. Am. J. Gastroenterol. 92, 332–334 (1997).

    CAS  PubMed  Google Scholar 

  8. Huizinga, J.D. et al. W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373, 347–349 (1995).

    Article  CAS  PubMed  Google Scholar 

  9. Sanders, K.M. A case for interstitial cells of Cajal as pacemakers and mediators of neurotransmission in the gastrointestinal tract. Gastroenterology 111, 492–515 (1996).

    Article  CAS  PubMed  Google Scholar 

  10. Burns, A.J. et al. Interstitial cells of Cajal mediate inhibitory neurotransmission in the stomach. Proc. Natl. Acad. Sci. USA 93, 12008–12013 (1996).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Huizinga, J.D., Thunderberg, L., Vanderwinden, J.M. & Rumessen, J.J. Interstitial cells of Cajal as targets for pharmacological intervention in gastrointestinal motor disorders Trends. Pharmacol. Sci. 18, 393–403 (1997).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Brain Research Unit Faculté de Médecine, Universiteé Libre de Bruxelles, Brussels, Belgium

    Jean-Marie Vanderwinden & Jean-Jacques Vanderhaeghen

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  1. Jean-Marie Vanderwinden
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  2. Jean-Jacques Vanderhaeghen
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Vanderwinden, JM., Vanderhaeghen, JJ. Keeping up with the Cajal rhythm. Nat Med 4, 765–767 (1998). https://doi.org/10.1038/nm0798-765

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