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Anticonvulsant action of neuropeptide Y

Nature Medicine volume 3, pages 728–729 (1997)Cite this article

Neuropeptide Y may act as an endogenous anticonvulsant through Y5 receptors suggesting a new target for antiepileptic drugs (pages 761–764).

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References

  1. White, J.D. Neuropeptide Y: A central regulator of energy homeostasis. Regul. Pept. 49, 93–107 (1996).

    Article  Google Scholar 

  2. Gerald, C. et al. A receptor subtype involved in neuropeptide γ-induced food intake. Nature 382, 168–171 (1996).

    Article  CAS  Google Scholar 

  3. Hu, Y. et al. Identification of a novel hypothalamic neuropeptide Y receptor associated with feeding behavior. J. Biol. Chem. 271, 26315–26319 (1996).

    Article  CAS  Google Scholar 

  4. Erickson, J.C., Clegg, K.E. & Palmiter, R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381, 415–418 (1996)

    Article  CAS  Google Scholar 

  5. Woldbye, D.P.D., Madsen, T.M., Larsen, P.J., Mikkelsen, J.D. & Bolwig, T.G. Powerful inhibition of kainic acid seizures by neuropeptide γ via γ5-like receptors. Nature Med. 3, 761–764 (1997).

    Article  CAS  Google Scholar 

  6. Colmers, W.F. & Bleakman, D. Effects of neuropeptide γ on the electrical properties of neurons. TINS 17, 373–379 (1994).

    CAS  PubMed  Google Scholar 

  7. Smialowska, M., Bijak, M., Sopala, M. & Tokarski, K. Inhibitory effect of NPY on the picrotoxin-induced activity in the hippocampus: a behavioral and electrophysiological study. Neuropeptides 30, 7–12 (1996)

    Article  CAS  Google Scholar 

  8. Woldbye, D.P.D., Madsen, T.M., Larsen, P.J., Mikkelsen, J.D. & Bolwig, T.G. Neuropeptide γ inhibits hippocampal seizures and wet dog shakes. Brain Res. 737, 162–168 (1996).

    Article  CAS  Google Scholar 

  9. Bard, J.A., Walker, M.W., Branchek, T.A. & Weinshank, R.L. Cloning and functional expression of a human γ4 subtype receptor for pancreatic polypeptide, neuropeptide γ and peptide γ γ. J. Biol. Chem. 270, 26762–26765 (1995).

    Article  CAS  Google Scholar 

  10. Blomqvist, A.G. & Herzog, H. γ-receptor subtypes — how many more? TINS (1997) in press.

  11. Dumont, Y., Fournier, A., St-Pierre, S. & Quiron, R. Autoradiographic distribution of [125l][Leu31, Pro34]-PYY and [1251] PYY 3–36 binding sites in the rat brain evaluated with two newly developed γ1 and γ2 receptor radioligands. Synapse 22, 139–158 (1996).

    Article  CAS  Google Scholar 

  12. Haas, H.L., Hermann, A., Greene, R.W. & ChanPalay, V. Action and location of neuropeptide tyrosine (γ) on hippocampal neurons of the rat in slice preparations. J. Comp. Neurol. 257, 208–215 (1987).

    Article  CAS  Google Scholar 

  13. Marksteiner, J., Ortler, M., Bellmann, R. & Sperk, G. Neuropeptide Y biosynthesis is markedly induced in mossy fibers during temporal lobe epilepsy of the rat. Neurosci. Lett. 112, 143–148 (1990).

    Article  CAS  Google Scholar 

  14. Roder, C. et al. Autoradiographic analysis of neuropeptide Y receptor binding sites in the rat hippocampus after kainic acid-induced limbic seizures. Neuroscience 70, 47–55 (1996).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Pharmacology University Innsbruck, Peter-Mayr-Str. 1a, 6020, Innsbruck, Australia

    Günther Sprerk

  2. Garvan Institute for Medical Research, Neurobiology Program, Sydney, Australia

    Herbert Herzog

Authors
  1. Günther Sprerk
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  2. Herbert Herzog
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Sprerk, G., Herzog, H. Anticonvulsant action of neuropeptide Y. Nat Med 3, 728–729 (1997). https://doi.org/10.1038/nm0797-728

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