Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Double indemnity: p53, BRCA and cancer

p53 mutation partially rescues developmental arrest in Brca1 and Brca2 null mice, suggesting a role for familial breast cancer genes in DNA damage repair.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Miki, Y. et al. A strong candidate for the breast and ovarian-cancer susceptibility gene. Science 266, 66–71 (1994).

    Article  CAS  Google Scholar 

  2. Wooster, R. et al. Identification of the breast cancer susceptibility gene BRCA2. Nature 378, 789–792 (1995).

    Article  CAS  Google Scholar 

  3. Coene, E. et al. BRCA1 is localized in cytoplasmic tube-like imaginations in the nucelus. Nature Genet. 16, 121–123 (1997).

    Article  Google Scholar 

  4. Scully, R. et al. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell 88, 265–275 (1997).

    Article  CAS  Google Scholar 

  5. Chapman, M.S. et al. Transcription activation by BRCA1. Nature 382, 678–679 (1996).

    Article  CAS  Google Scholar 

  6. Milner, J. et al. Transcriptional activation functions in BRCA2. Nature 386, 772–773 (1997).

    Article  CAS  Google Scholar 

  7. Sharan, S.K. et al. Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2. Nature 386, 804–810 (1997).

    Article  CAS  Google Scholar 

  8. Shinohara, A. et al. Rad51 protein involved in repair and recombination in S. Cerevesiae is a Rec-A like protein. Cell 69, 457–470 (1992).

    Article  CAS  Google Scholar 

  9. Carr, A.M. et al. The cellular responses to DNA damage. TICS 5, 32–40 (1995).

    CAS  Google Scholar 

  10. Lim, D. et al. A mutation in rad 51 results in an early embryonic lethal that is suppressed by a mutationin p53. Mol. Cell. Biol. 16, 7133–7143 (1996).

    Article  CAS  Google Scholar 

  11. Jacks, T. Tumor suppressor gene mutations in mice. Annu. Rev. Genet. 30, 603–636 (1996).

    Article  CAS  Google Scholar 

  12. Hakem, R. et al. The tumor suppressor gene Brcal is required for embryonic cellular proliferation in the mouse. Cell 85, 1009–1023 (1996).

    Article  CAS  Google Scholar 

  13. Liu, C. et al. Inactivation of the mouse Brcal gene leads to failure in the morphogenesis of the egg cylinder in early postimplantation development. Genes & Dev. 10, 1835–1843 (1996).

    Article  CAS  Google Scholar 

  14. Ludwig, T. et al. Targeted mutations of breast cancer susceptibility gene homologs in mice: lethal. phenotypes of Brcal, Brca2, Brcal/Brca2, Brcal/p53, and Brca2/p53 nullizygous embryos. Genes & Dev. 11, 1226–1241 (1997).

    Article  CAS  Google Scholar 

  15. Suzuki, A. et al. Brca2 is required for embryonic cellular proliferation in the mouse. Genes & Dev. 11, 1242–1252 (1997).

    Article  CAS  Google Scholar 

  16. El-Deiry, W.S. et al. WAF1, a potential mediator of p53 tumor suppression. Cell 75, 817–825 (1993).

    Article  CAS  Google Scholar 

  17. Brugarolas, J. et al. Radiation-induced cell cycle arrest compromised by p21 deficiency. Nature 377, 552–557 (1995).

    Article  CAS  Google Scholar 

  18. Deng, C. et al. Mice Lacking p21 CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell 82, 675–684 (1995).

    Article  CAS  Google Scholar 

  19. Hakem, R. et al. Rescue of Brca1 early embryonic lethality by p53 or p21 null mutation. Nature Genet. 16, 298–302 (1997).

    Article  CAS  Google Scholar 

  20. Tsuzuki, T. et al. Targeted disruption of the Rad51 gene leads to lethality in embryonic mice. Proc. Natl. Acad. Sci. USA 93, 6236–6240 (1996).

    Article  CAS  Google Scholar 

  21. Glebov, O.K. et al. Frequent p53 gene mutations and novel alleles in familial breast cancer. Cancer Res. 54, 3703–3709 (1994).

    CAS  Google Scholar 

  22. Boyd, M. et al. A human BRCA1 gene knockout. Nature 375, 541–542 (1995).

    Article  CAS  Google Scholar 

  23. Jones, S.N. et al. Rescue of embryonic lethality in Mdm-2 deficient mice by absence of p53. Nature 378, 206–208 (1996).

    Article  Google Scholar 

  24. Montes de Oca Luna, R. et al. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378, 203–206 (1995).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brugarolas, J., Jacks, T. Double indemnity: p53, BRCA and cancer. Nat Med 3, 721–722 (1997). https://doi.org/10.1038/nm0797-721

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0797-721

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing