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References
Lichtenberger, L.M. et al. Non-steroidal anti-inflammatory drugs (NSAIDs) associate with zwit-terionic phospholipids: Insight into the mechanism and reversal of NSAID-induced gastrointestinal injury. Nature Med. 1, 154–158 (1995).
Tanaka, T., Bickel, M., Herling, A.W., Sakurai, M. & Goto, M. Effects of the novel anti-ulcer agent 1-(5′-oxohexyl)-3-methyl-7-propyl xanthine on experimental ulcers and gastric secretion in rats. Arzneim.-Forsch./Drug Res. 39, 689 (1989).
Brzozowski, T., Majka, J. & Stachura, J. Adaptation of the gastric mucosa to stress and aspirin (ASA). Role of sensory nerves, prostaglandins (PG) and epidermal growth factor (EGF). Gastroenterology 104, A48, (1993).
Whittle, B.J.R., Higgs, G.A., Eakins, K.E., Moncada, S. & Vane, J.R. Selective inhibition of prostaglandin production in inflammatory exu-dates and gastric mucosa. Nature 284, 271–273 (1980).
Robert, A. Gastric cytoprotection by sodium salicylate. Prostaglandins 21, 139–146 (1981).
Brown, J.F., Hanson, P.J. & Whittle, B.J.R. Nitric oxide donors increase mucus gel thickness in rat stomach. Eur. J. Pharmac. 223, 103–104 (1992).
Pique, J.M., Whittle, B.J.R. & Esplugues, J.V. The vasodilator role of endogenous nitric oxide in the rat gastric microcirculation. Eur. J. Pharmac. 174, 293–296 (1989).
Whittle, B.J.R. Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and the gastrointestinal damage induced by indomethacin in the rat. Gastroenterology 80, 94–98 (1981).
Rainsford, K.D. & Willis, C. Relationship of gastric mucosal damage induced in pigs by anti-inflammatory drugs to their effects on prostaglandin production. Dig. Dis. Sci. 27, 624–635 (1982).
Ligumsky, M., Golanska, E.M., Hansen, D.G. & Kauffman, G.L. Jr. Aspirin can inhibit gastric mucosal cyclo-oxygenase without causing lesions in the rat. Gastroenterology 84, 756–761 (1983).
Vane, J.R. Inhibition of prostaglandin synthesis as a mechanism of action of aspirin-like drugs. Nature (New Biology) 231, 232–235 (1971).
Ferreira, S.H. & Vane, J.R. New aspects of the mode of action of nonsteroicj anti-inflammatory drugs. Annu. Rev. Pharmac. 14, 57–71 (1974).
Vane, J.R., Flower, R.J. & Salmon, J.A. Inhibitors of arachidonic acid metabolism, with especial reference to the aspirin-like drugs, in Prostaglandins and Related Lipids, Vol 2 Prostaglandins and Cancer (eds, Powels, T. J., Bockman, R.S., Honn, K.V. & Ramwell, P.) 21–45 (Liss, New York, 1982).
Wu, K.K., Sanduja, R. & Tsai, A.L. Aspirin inhibits interleukin-1-induced prostaglandin H synthase expression in cultured endothelial cells. Proc. natn. Acad. Sci. U.S.A. 88, 2384–2387 (1991).
Vane, J.R. & Botting, R.M. Aspirin and Other Salicylates (Chapman & Hall Medical, London, 1992).
Davenport, H.W. Damage of the gastric mucosa: effects of salicylates and stimulation. Gastroenterology 49, 189–196 (1965).
Rainsford, K.D. Side-effects and toxicology of the salicylates. in Aspirin and the Salicylates (ed. Rainsford, K.D.) 148–220 (Butterworths, London, 1984).
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Reply to — Aspirin, salicylate and gastrointestinal injury. Nat Med 1, 602–603 (1995). https://doi.org/10.1038/nm0795-602b
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DOI: https://doi.org/10.1038/nm0795-602b