Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Taking aim at HIV replication

Impressive progress has been made in the development of drugs that inhibit human immunodeficiency virus replication. A new study indicates that mycophenolic acid, a selective inhibitor of lymphocyte proliferation, might also be useful in controlling viral replication through several mechanisms (pages 762–768).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: When resting CD4+ T cells encounter the appropriate foreign antigen (Ag), they enlarge, enter the cell cycle and proliferate.

Bob Crimi

References

  1. Gulick, R.M. et al. Treatment with indinavir, zidovudine, and lamivudine in adults with human immunodeficiency virus infection and prior antiretroviral therapy . N. Engl. J. Med. 337, 734– 739 (1997).

    Article  CAS  Google Scholar 

  2. Hammer, S.M. et al. A controlled trial of two nucleoside analogues plus indinavir in persons with human immunodeficiency virus infection and CD4 cell counts of 200 per cubic millimeter or less. AIDS Clinical Trials Group 320 Study Team. N. Engl. J. Med. 337, 725– 733 (1997).

    Article  CAS  Google Scholar 

  3. Palella, F.J. et al. Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. N. Engl. J. Med. 338, 853–860 (1998).

    Article  Google Scholar 

  4. Chapuis, A.G. et al. Effects of mycophenolic acid on human immunodeficiency virus infection in vitro and in vivo. Nature Med. 6, 762–768 (2000).

    Article  CAS  Google Scholar 

  5. Haase, A.T. Population biology of HIV-1 infection: Viral and CD4+ T cell demographics and dynamics in lymphatic tissues. Annu. Rev. Immunol. 17, 625–656 (1999).

    Article  CAS  Google Scholar 

  6. Chun, T.-W. et al. Fate of HIV-1-infected T cells in vivo: Rates of transition to stable latency. Nature Med. 1, 1284– 1290 (1995).

    Article  CAS  Google Scholar 

  7. Dornadula, G. et al. Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy. J. Am. Med. Assoc. 282, 1627–1632 (1999).

    Article  CAS  Google Scholar 

  8. Margolis, D. et al. Abacavir and mycophenolic acid, an inhibitor of inosine monophosphate dehydrogenase, have profound and synergistic anti-HIV activity. J. Acquir. Immune Defic. Syndr. 21, 362– 370 (1999).

    Article  CAS  Google Scholar 

  9. Finzi, D. et al. Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy. Science 278, 1295–1300 (1997).

    Article  CAS  Google Scholar 

  10. Wong, J.K. et al. Recovery of replication-competent HIV despite prolonged suppression of plasma viremia. Science 278, 1291– 1295 (1997).

    Article  CAS  Google Scholar 

  11. Chun, T.W. et al. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc. Natl. Acad. Sci. USA 94, 13193–13197 (1997).

    Article  CAS  Google Scholar 

  12. Finzi, D. et al. Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy. Nature Med. 5, 512– 517 (1999).

    Article  CAS  Google Scholar 

  13. Lori, F. et al. Hydroxyurea as an inhibitor of human immunodeficiency virus-type 1 replication. Science 266, 801– 805 (1994).

    Article  CAS  Google Scholar 

  14. Lori, F. et al. Treatment of human immunodeficiency virus infection with hydroxyurea, didanosine, and a protease inhibitor before seroconversion is associated with normalized immune parameters and limited viral reservoir. J. Infect. Dis. 180, 1827–1832 ( 1999).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Finzi, D., Siliciano, R. Taking aim at HIV replication. Nat Med 6, 735–736 (2000). https://doi.org/10.1038/77444

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/77444

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing