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Progress of the smart bomb cancer virus

Nature Medicine volume 3, pages 606–608 (1997)Cite this article

A mutant adenovirus capable of preferentially destroying cancer cells shows promise in preclinical studies (639–645).

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References

  1. Bischoff, J.R. et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science 274, 373–376 (1996).

    Article  CAS  Google Scholar 

  2. Heise, C. et al. ONXY-015, an El B gene-attenuated adenovirus, causes tumor-specific cytolysis and antitumoral efficacy that can be augmented by standard chemotherapeutic agents. Nature Med. 3, 639–645 (1997).

    Article  CAS  Google Scholar 

  3. Weinberg, R. A. The cat and mouse games that genes, viruses, and cells play. Cell 88, 573–575 (1997).

    Article  CAS  Google Scholar 

  4. Lowe, S.W. & Ruley, H.E. Stabilization of the p53 tumor suppressor is induced by adenovirus E1A and accompanies apoptosis. Genes Dev. 7, 535–545 (1993).

    Article  CAS  Google Scholar 

  5. Grand, R.J.A., Grant, M.L. & Gallimore, P.H. Enhanced expression of p53 in human cells infected with mutant adenoviruses. Virology 203, 229–240 (1994).

    Article  CAS  Google Scholar 

  6. Debbas, M. & White, E. Wildtype p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7, 546–554 (1993).

    Article  CAS  Google Scholar 

  7. Yew, P.R. & Berk, A.J. Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357, 82–85 (1992).

    Article  CAS  Google Scholar 

  8. Lowe, S.W., Ruley, H.E., Jacks, T. & Housman, D.E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74, 954–967 (1993).

    Article  Google Scholar 

  9. Somasundaram, K. & El-Deiry, W.S. Inhibition of p53-mediated transactivation and cell cycle arrest by E1 A through its p300/CBP-interacting region. Oncogene 14, 1047–1057 (1997).

    Article  CAS  Google Scholar 

  10. Dobner, T., Horikoshi, N., Rubenwolf, S. & Shenk, T. Blockage by adenovirus E41orf6 of transcriptional activation by the p53 tumor suppressor. Science 272, 1470–1473 (1996).

    Article  CAS  Google Scholar 

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  1. Cold Spring Harbor Laboratory, Cold Spring Harbor, NY, 11724

    Scott W. Lowe

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  1. Scott W. Lowe
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Lowe, S. Progress of the smart bomb cancer virus. Nat Med 3, 606–608 (1997). https://doi.org/10.1038/nm0697-606

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