Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Fighting HIV-1 with IL-16

Nature Medicine volume 3, pages 605–606 (1997)Cite this article

Replication of HIV-1 is halted in human CD44 T cells engineered to express interleukin 16, suggesting a novel gene therapy approach to combat HIV infection (659–664).

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

References

  1. Levy, A. J., Mackewicz, C. E. & Barker, E. Barker, E. Controlling HIV pathogenesis: the role of the non-cytotoxic anti-HIV response of CD8+ T cells. Science 17, 218–224 (1996).

    Google Scholar 

  2. Cocchi, F. et al. Identification of RANTES, MIP-1α and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science 270, 1811–1815 (1995).

    Article  CAS  Google Scholar 

  3. Baier, M., Werner, A., Bannert, N., Metzner, K. & Kurth, R. HIV suppression by IL-16. Nature 378, 563 (1995).

    Article  CAS  Google Scholar 

  4. Zhou, P., Goldstein, S., Devadas, K., Tewari, D. & Notkins, A.L. Human CD4+ cells transfected with IL-16 cDNA are resistant to HIV-1 infection: inhibition of mRNA expression. Nature Med. 3, 659–664 (1997).

    Article  CAS  Google Scholar 

  5. Center, D.M., Kornfeld, H. & Cruikshank, W.W. Interleukin 16 and its function as a CD4 ligand. Immunol. Today 17, 476–481 (1996).

    Article  CAS  Google Scholar 

  6. Baier, M., Bannert, N., Werner, A., Lang, K. & Kurth, R. Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor. Proc Natl. Acad. Sci. USA (1997)in press.

  7. Benkirane, M.D., Corbeau, P., Housset, V. & Deveaux, C. An antibody that binds the immunoglobulin CDR3-like region of the CD4 molecule inhibits provirus transcription in HIV-infected T cells. EMBO J. 12, 4909–4921 (1993).

    Article  CAS  Google Scholar 

  8. Tremblay, M., Meloche, S., Gratton, s., Wainberg, M.A. & Sekaly, R.-P. Association of p56-lck with the cytoplasmic domain of CD4 modulates HIV-1 expression. EMBO J. 13, 774–783 (1994).

    Article  CAS  Google Scholar 

  9. Fauci, A.S. Host factors and the pathogenesis of HIV-induced disease. Nature 384, 529–534 (1996).

    Article  CAS  Google Scholar 

  10. Schmidtmayerova, H., Sherry, B. & Bukrinsky, M. Chemokines and HIV-replication. Nautre 382, 767 (1996).

    Article  CAS  Google Scholar 

  11. Guidotti, L.G. et al. Intracellular inactivation of the hepatitis B virus by cytotoxic T cells. Immunity 4, 25–36 (1996).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Paul-Ehrlich-Institutm, 63225, Langen, Germany

    Michael Baier & Reinhard Kurth

Authors
  1. Michael Baier
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Reinhard Kurth
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Baier, M., Kurth, R. Fighting HIV-1 with IL-16. Nat Med 3, 605–606 (1997). https://doi.org/10.1038/nm0697-605

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0697-605

This article is cited by

Search

Advanced search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing