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A sensitive defense: Salt and cystic fibrosis

Nature Medicine volume 3, pages 494–495 (1997)Cite this article

New evidence implicates salt-sensitive, natural antibiotics in lung mucosal defenses and may explain how a defective chloride channel leads to lung infections.

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References

  1. di Sant′Agnese, P. et al. Sweat electrolyte disturbances associated with childhood pancreatic disease. Am. J. Med. 15, 777–784 (1953).

    Article  Google Scholar 

  2. Quinton, P.M. Chloride impermeability in cystic fibrosis. Nature 301, 421–422 (1983).

    Article  CAS  Google Scholar 

  3. Smith, J.J., Travis, S.M., Greenberg, E.P. & Welsh, M.J. Cystic fibrosis airway epithelia fail to kill bacteria because of abnormal airway surface fluid. Cell 85, 229–236 (1996).

    Article  CAS  Google Scholar 

  4. Zasloff, M., Magainins, a class of antimicrobial peptides from Xenopusskin: Isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. USA 84, 5449–5453 (1987).

    Article  CAS  Google Scholar 

  5. Bensch, K.W. et al. hBD-1: A novel beta-defensin from human plasma. FEBS Lett. 368, 331–335 (1995).

    Article  CAS  Google Scholar 

  6. McCray, P.B. & Bentley, L. Human airway epithelia express a β-defensin. Am. J. Respir. Cell Mol. Biol. 16, 343–349 (1997).

    Article  CAS  Google Scholar 

  7. Goldman, M.J. et al. Human β-defensin-1 is a salt-sensitive antibiotic in lung that is inactivated in cystic fibrosis. Cell 88, 553–560 (1997).

    Article  CAS  Google Scholar 

  8. Boucher, R.C. et al. Na+ transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J. Clin. Invest. 78, 1245–1252 (1986).

    Article  CAS  Google Scholar 

  9. Basbaum, C.B., Jany, B. & Finkbeiner, W.E. The serous cell. Annu. Rev. Physiol. 52, 97–113 (1990).

    Article  CAS  Google Scholar 

  10. Engelhardt, J.F. et al. Submucosal glands are the predominant site of CFTR expression in the human bronchus. Nature Genet. 2, 240–248 (1992).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Cystic Fibrosis Research Laboratory, Stanford University Stanford, California, 94305-2130, USA

    Jeffrey J. Wine

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  1. Jeffrey J. Wine
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Wine, J. A sensitive defense: Salt and cystic fibrosis. Nat Med 3, 494–495 (1997). https://doi.org/10.1038/nm0597-494

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