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What is leptin for, and does it act on the brain?

Nature Medicine volume 2, pages 492–493 (1996)Cite this article

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References

  1. Zhang, Y. et al. Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425–431 (1994).

    Article  CAS  Google Scholar 

  2. Considine, R.V. et al. Serum immunoreactiveleptin concentrations in normal-weight and obese humans. New Engl. J. Med. 334, 292–295 (1996).

    Article  CAS  Google Scholar 

  3. Frederich, R.C. et al. Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action. Nature Med. 1, 1311–1314 (1995).

    Article  CAS  Google Scholar 

  4. Halaas, J.L. et al. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269, 543–546 (1995).

    Article  CAS  Google Scholar 

  5. Campfield, L.A., Smith, F.J., Guisez, Y., Devos, R. & Burn, P. Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269, 546–549 (1995).

    Article  CAS  Google Scholar 

  6. Chehab, F.E., Lim, M.E. & Lu, R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nature Genet. 12, 318–320 (1996).

    Article  CAS  Google Scholar 

  7. Tartaglia, L.A. et al. Identification and expression cloning of a leptin receptor, OB-R. Cell 83, 1263–1271 (1995).

    Article  CAS  Google Scholar 

  8. Levin, N., Nelson, C., Gurney, A., Vandlen, R. & de Sauvage, F. Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc. Natl. Acad. Sci. USA 93, 1726–1730 (1996).

    Article  CAS  Google Scholar 

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  1. Department of Brain & Cognitive Sciences, and Clinical Research Center, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Richard J. Wurtman

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  1. Richard J. Wurtman
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Wurtman, R. What is leptin for, and does it act on the brain?. Nat Med 2, 492–493 (1996). https://doi.org/10.1038/nm0596-492

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