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Slowing ageing by caloric restriction

Dietary caloric restriction is the only intervention conclusively shown to slow ageing, delay the onset of age-related diseases, maintain function and extend both median and maximal life span in mammals.

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References

  1. Weindruch, R. & Walford, R. The Retardation of Aging and Disease by Dietary Restriction (Thomas, Springfield, Illinois, 1988).

    Google Scholar 

  2. Ingram, D.K. et al. Dietary restriction and aging: The initiation of a primate study. J. Geront. biol. Sci. 45, B148–B163 (1990).

    Article  CAS  Google Scholar 

  3. Kemitz, J.W. et al. Dietary restriction of adult male rhesus monkeys: Design, methodology and preliminary findings from the first year of study. J. Geront. biol. Sci. 48, B17–B26 (1993).

    Article  Google Scholar 

  4. Bodkin, N. et al. Long-term dietary restriction in older-aged rhesus monkeys: Effects on insulin resistance. J. Geront. biol. Sci. (in the press).

  5. Beregi, E. Centenarians in Hungary (Karger, Basel, Switzerland, 1990).

    Google Scholar 

  6. Masoro, E.J. et al. Dietary restriction alters characteristics of glucose fuel use. J. Geront. biol. Sci. 47, B202–B208 (1992).

    Article  CAS  Google Scholar 

  7. Yu, B.P. Free Radicals in Aging (CRC Press, Boca Raton, Florida, 1993).

    Google Scholar 

  8. Reiser, K.M. Influence of age and long-term dietary restriction on enzymatically mediated crosslinks and nonenzymatic glycation pf collagen in mice. J. Geront. biol. Sci. 49, B71–B79 (1994).

    Article  CAS  Google Scholar 

  9. Pahlavani, M.A. et al. Influence of dietary restriction on gene expression: Changes in the transcription of specific genes. in Modulation of Aging Processes by Dietary Restriction (ed. Yu, B.P.) 143–156 (CRC Press, Boca Raton, FL, 1994).

    Google Scholar 

  10. Sabatino, F. et al. Assessment of the role of the glucocorticoid system in aging processes and in the action of food restriction. J. Geront. biol. Sci. 46, B171–B179 (1991).

    Article  CAS  Google Scholar 

  11. Heydari, A.R. et al. Expression of heat shock genes in hepatocytes is affected by age and food restriction in rats. J. Nutr. (in the press).

  12. Roth, G.S. et al. Age-related changes in androgen levels of rhesus monkeys subjected to dietary restriction. Endocr. J. 1, 227–234 (1993).

    Google Scholar 

  13. Lane, M.A. et al. The influence of aging and dietary restriction on bone metabolism in male rhesus (Macaca mulatto) monkeys. J. Nutr. (in the press).

  14. Roth, G.S. Entropy theories of aging revisited. Aging din. exp. Res. 6, 139–140 (1994).

    Article  CAS  Google Scholar 

  15. Harman, D. The aging process. Proc. natn. Acad. Sci. USA. 78, 7124–7128 (1981).

    Article  CAS  Google Scholar 

  16. Dark, J. et al. Reduced glucose availability induces torpor in Siberian hamsters. Am. J. Physiol. 267, R496–R501 (1994).

    CAS  PubMed  Google Scholar 

  17. Lee, A.S. et al. Transcriptional regulation of two genes specifically induced by glucose starvation in a hamster mutant fibroblast cell line. J. biol. Chem. 258, 597–603 (1983).

    CAS  PubMed  Google Scholar 

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Roth, G., Ingram, D. & Lane, M. Slowing ageing by caloric restriction. Nat Med 1, 414–415 (1995). https://doi.org/10.1038/nm0595-414

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