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Steering anti-cancer drugs away from the TRAIL

TRAIL, a cytokine of the TNF family, has been hyped as an almost ‘magical’ drug for cancer treatment. However, its possible side effects in the liver raise serious concerns about its likelihood for development into a safe therapeutic product (pages 564–567 ).

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References

  1. Old, L.J. Tumor necrosis factor (TNF). Science 230, 630–632 (1985).

    Article  CAS  Google Scholar 

  2. Vassalli, P. The pathophysiology of tumor necrosis factors. Annu. Rev. Immunol. 10, 411–452 ( 1992).

    Article  CAS  Google Scholar 

  3. Trauth, B.C. et al. Monoclonal antibody-mediated tumor regression by induction of apoptosis. Science 245, 301– 305 (1989).

    Article  CAS  Google Scholar 

  4. Ogasawara, J. et al. Lethal effect of the anti-Fas antibody in mice. Nature 364, 806–809 ( 1993).

    Article  CAS  Google Scholar 

  5. Willey, S.R. et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity 3, 673–682 (1995).

    Article  Google Scholar 

  6. Pitti, R.M. et al. Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family. J. Biol. Chem. 271, 12687–12690 (1996).

    Article  CAS  Google Scholar 

  7. Walczak, H. et al. Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nature Med. 5, 157 –163 (1999).

    Article  CAS  Google Scholar 

  8. Ashkenazi, A. et al. Safety and antitumor activity of recombinant soluble Apo2 ligand. J. Clin. Invest. 104, 155– 162 (1999).

    Article  CAS  Google Scholar 

  9. Jo, M. et al. TNF-related apoptosis inducing ligand (TRAIL)-induced apoptosis in normal human hepatocytes. Nature Med. 6, 564–567 (2000)

    Article  CAS  Google Scholar 

  10. Nagata, S. Apoptosis by death factor. Cell 88, 355– 365 (1997).

    Article  CAS  Google Scholar 

  11. Ashkenazi, A. & Dixit, V.M. Death receptors: signaling and modulation . Science 281, 1305–1308 (1998).

    Article  CAS  Google Scholar 

  12. Nagata, S. Fas ligand-induced apoptosis. Annu. Rev. Genetics 33 , 29–55 (1999).

    Article  CAS  Google Scholar 

  13. Bodmer, J.-L. et al. TRAIL receptor-2 signals apoptosis through FADD and caspase-8 . Nature Cell Biol. 2, 241– 243 (2000).

    Article  CAS  Google Scholar 

Download references

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Nagata, S. Steering anti-cancer drugs away from the TRAIL. Nat Med 6, 502–503 (2000). https://doi.org/10.1038/74972

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