TRAIL, a cytokine of the TNF family, has been hyped as an almost ‘magical’ drug for cancer treatment. However, its possible side effects in the liver raise serious concerns about its likelihood for development into a safe therapeutic product (pages 564–567 ).
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Apoptosis induction in renal cell carcinoma by TRAIL and γ-radiation is impaired by deficient caspase-9 cleavage
British Journal of Cancer Open Access 27 May 2003
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Nagata, S. Steering anti-cancer drugs away from the TRAIL. Nat Med 6, 502–503 (2000). https://doi.org/10.1038/74972
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DOI: https://doi.org/10.1038/74972
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