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Linking Helicobacter pylori to gastric cancer

Nature Medicine volume 6, pages 376–377 (2000)Cite this article

Although Helicobacter pylori affects a large percentage of the population, only a small percentage of carriers develop peptic ulcers and gastric cancer. Recent investigations have begun to identify the factors that lead to these complications.

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Figure 1: Equilibrium model of long-term colonization of the stomach by H. pylori.

Bob Crimi

References

  1. Blaser, M.J. The changing relationships of Helicobacter pylori and humans: implications for health and disease. J. Infect. Dis. 179, 1523–1530 (1999).

    Article  CAS  Google Scholar 

  2. El-Omar E. et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature 404, 398–402 (2000).

    Article  CAS  Google Scholar 

  3. Wang, G., Humayun, M.Z. & Taylor, D.E. Mutation as an origin of genetic variability in Helicobacter pylori. Trends Micribiol 7, 488–493 (1999).

    Article  CAS  Google Scholar 

  4. Gerhard, M. et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc. Natl. Acad. Sci. USA 96, 12778–12783 (1999).

    Article  CAS  Google Scholar 

  5. Blaser, M.J., Chyou, P.H. & Nomura, A. Age at establishment of Helicobacter pylori infection and gastric carcinoma, gastric ulcer, and duodenal ulcer risk. Cancer Res 55, 562–565 (1995).

    CAS  PubMed  Google Scholar 

  6. Nomura, A., Grove, J.S., Stemmerman, G.N. & Severson, R.K. A prospective study of stomach cancer and its relation to diet, cigarettes, and alcohol consumption. Cancer Res 50:627–631 (1990).

    CAS  PubMed  Google Scholar 

  7. Noach, L.A. et al. Mucosal tumor necrosis factor-α, interleukin-1β, and interleukin-8 production in patients with Helicobacter pylori infection. Scand. J. Gastroenterol 29, 425–429 (1994).

    Article  CAS  Google Scholar 

  8. Beales, I.L. & Calam, J. Interleukin 1β and tumour necrosis factor α inhibit acid secretion in cultured rabbit parietal cells by multiple pathways. Gut, 42, 227–234 (1998).

    Article  CAS  Google Scholar 

  9. Blaser, M.J. Ecology of Helicobacter pylori in the human stomach. J. Clin. Invest. 100, 759–762 (1997).

    Article  CAS  Google Scholar 

  10. Blaser, M.J. & Kirschner, D. Dynamics of Helicobacter pylori colonization in relation to the host response. Proc. Natl. Acad. Sci. USA 96, 8359–8364 (1999).

    Article  CAS  Google Scholar 

  11. Tummuru, M.K.R., Sharma, S.A. & Blaser, M.J. Helicobacter pylori picB, a homologue of the Bordetella pertussis toxin secretion protein, is required for induction of IL-8 in gastric epithelial cells. Mol. Microbiol. 18, 867–876 (1995).

    Article  CAS  Google Scholar 

  12. Odenbreit, S. et al. Translocation of Helicobacter pylori CagA into gastric epithelial cells by type IV secretion. Science 287, 1497–1500 (2000).

    Article  CAS  Google Scholar 

  13. Crabtree, J.E., Kersulyte, D., Li, S.D., Lindley, I.J.D. & Berg, D.E. Modulation of Helicobacter pylori induced interleukin-8 synthesis in gastric epithelial cells mediated by cag PAI encoded VirD4 homologue. J. Clin. Path 52, 653–657 (1999).

    Article  CAS  Google Scholar 

  14. Kuipers, E.J. et al. Quasispecies development of Helicobacter pylori observed in paired isolates obtained years apart in the same host. J. Infect. Dis 181, 273–82 (2000).

    Article  CAS  Google Scholar 

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  1. Division of Infectious Diseases Vanderbilt University School of Medicine, A3310 Medical Center North, Nashville, 37232-2605, Tennessee, USA

    Martin J. Blaser

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  1. Martin J. Blaser
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Blaser, M. Linking Helicobacter pylori to gastric cancer. Nat Med 6, 376–377 (2000). https://doi.org/10.1038/74627

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