Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Cuts and scrapes? Plasmin heals!

The healing of skin wounds is severely affected in mice with a targeted disruption of the plasminogen gene (pages 287–292).

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Rømer, J. et al. Impaired wound healing in mice with a disrupted plasminogen gene. Nature Med. 2, 287–292 (1996).

    Article  Google Scholar 

  2. Vassalli, J.-D., Sappino, A.P. & Belin, D. The plasminogen activator/plasmin system. J. Clin. Invest. 88, 1067–1072 (1991).

    Article  CAS  Google Scholar 

  3. Carmeliet, P. et al. Physiological consequences of loss of plasminogen activator gene function in mice. Nature 368, 419–424 (1994).

    Article  CAS  Google Scholar 

  4. Bugge, T.H., Flick, M.J., Daugherty, C.C. & Degen, J.L. Plasminogen deficiency causes severe thrombosis but is compatible with development and reproduction. Genes Dev. 9, 794–807 (1995).

    Article  CAS  Google Scholar 

  5. Morioka, S., Lazarus, G.S., Baird, J.L. & Jensen, P.L. Migrating keratinocytes express urokinase-type plasminogen activator. J. Invest. Dermatol. 88, 418–423 (1987).

    Article  CAS  Google Scholar 

  6. Grøndahl-Hansen, J., Lund, L.R., Ralfkiaer, E., Ottevanger, V. & Danønm>, K. Urokinase-and tissue-type plasminogen activators in keratinocytes during wound reepithelialization in vivo. J. Invest. Dermatol. 90, 790–795 (1988).

    Article  Google Scholar 

  7. Rømer, J. et al. The receptor for urokinase-type plasminogen activator is expressed by keratinocytes at the leading edge during re-epithelialization of mouse skin wounds. J. Invest. Dermatol. 102, 519–522 (1994).

    Article  Google Scholar 

  8. Werner, S. et al. The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 266, 819–822 (1994).

    Article  CAS  Google Scholar 

  9. Carmeliet, P. & Collen, D. Gene targeting and gene transfer studies of the plasminogen/plas-min system: Implications in thrombosis, hemo-stasis, neointima formation, and atherosclerosis. FASEB J. 9, 934–938 (1995).

    Article  CAS  Google Scholar 

  10. Westerhof, W., van Ginkel, C.J.W., Cohen, E.B. & Mekkes, J.R. Prospective randomized study comparing the debriding effect of krill enzymes and a non-enzymatic treatment in venous leg ulcers. Dermatologica 181, 293–297 (1990).

    Article  CAS  Google Scholar 

  11. Mulder, G., Jones, R., Cederholm-Williams, S., Cherry, G. & Ryan, T. Fibrin cuff lysis in chronic venous ulcers treated with a hydrocolloid dressing. Int. J. Dermatol. 32, 304–306 (1993).

    Article  CAS  Google Scholar 

  12. Dvorak, H.F., Wounds that do not heal. Similarities between tumor stroma generation and wound healing. N. Engl. J. Med. 315, 1650–1659 (1986).

    Article  CAS  Google Scholar 

  13. Sappino, A.P. et al. Differential protease expression by cutaneous squamous and basal Cell carcinomas. J. Clin. Invest. 88, 1073–1079 (1991).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Vassalli, JD., Saurat, JH. Cuts and scrapes? Plasmin heals!. Nat Med 2, 284–285 (1996). https://doi.org/10.1038/nm0396-284

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0396-284

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing