The brain is an isolated metabolic preserve and small metabolic biases that may have no consequences for other cells may have an important role in many neurological conditions.
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References
Li, X.-J. et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378, 398–402 (1995).
Burke, J.R. et al. Huntingtin and DRPLA proteins selectively interact with the enzyme GAPDH. Nature Med. 2, 347–350 (1996).
Gottesman, I.I. & Bertelsen, A. Confirming unexpressed genotypes for schizophrenia. Risks in the offspring of Fischer's Danish identical and fraternal discordant twins. Arch. Gen. Psychiatry 46, 867–872 (1989).
Bassett, A.S. & Honer, W.G. Evidence for anticipation in schizophrenia. Am. J. Hum. Genet. 54, 864–870 (1994).
Deng, H.X. et al. Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Science 261, 1047–1051 (1993).
Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein. Nature 373, 523–527 (1995).
Cai, X.D., Golde, T.E. & Younkin, S.G. Release of excess amyloid beta protein from a mutant amyloid beta protein precursor. Science 259, 514–516 (1993).
Sherrington, R. et al. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. Nature 375, 754–760 (1995).
Roses, A.D., Perspective: On the metabolism of apolipoprotein E and the Alzheimer diseases. Exp. Neurol. 132, 149–156 (1995).
Ueki, A., Kawano, M., Namba, Y., Kawakami, M. & Ikeda, K. A high frequency of apolipoprotein E4 isoprotein in Japanese patients with late-onset nonfamilial Alzheimer's disease. Neurosci. Lett. 163, 166–168 (1993).
Kuusisto, J. et al. Association of apolipoprotein E phenotypes with late onset Alzheimer's disease: Population based study. Br. Med. J. 309, 636–638 (1994).
Polvikoski, T. et al. Apolipoprotein E, dementia, and cortical deposition of beta-amyloid protein. N. Engl. J. Med. 333, 1242–1247 (1995).
Ohm, T.G. et al. Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation. Neuroscience 66, 583–587 (1995).
Strittmatter, W.J. et al. Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: Implications for Alzheimer disease. Proc. Natl. Acad. Sci. USA 91, 11183–11186 (1994).
Nathan, B.P. et al. The inhibitory effect of apolipoprotein E4 on neurite outgrowth is associated with microtubule depolymerization. J. Biol. Chem. 270, 19791–19799 (1995).
Holtzman, D.M. et al. Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous systemderived neuronal Cell line. Proc. Natl. Acad. Sci. USA 92, 9480–9484 (1995).
Huang, D.Y. et al. Isoform-specific interactions of apolipoprotein E with the microtubule associated protein MAP2c: Implications for Alzheimer's disease. Neumsci. Lett. 182, 55–58 (1994).
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Roses, A. From genes to mechanisms to therapies: Lessons to be learned from neurological disorders. Nat Med 2, 267–269 (1996). https://doi.org/10.1038/nm0396-267
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DOI: https://doi.org/10.1038/nm0396-267
