The leucine-rich repeat-containing gene, LGI1, was identified as a possible tumor suppressor gene involved in brain tumor development. It now appears that it also plays a role in abnormal brain development that leads to epilepsy.
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References
Meisler, M.H. et al. identification of epilepsy genes in human and mouse. Ann. Rev. Genet. 35, 567–588 (2001).
Kalachikov, S. et al. Mutations in LGI1 cause autosomal-dominant partial epilepsy with auditory features. Nature Genet. 30, 335–341 (2002).
Chernova, O. et al. A novel gene, LGI1, from region 10q24, is rearranged and downregulated in malignant brain tumors. Oncogene 17, 2873–2881 (1998).
Ottman, R. et al. Localization of a gene for partial epilepsy to chromosome 10q. Nature Genet. 10, 56–60 (1995).
Chernova, O. & Cowell, J.K. Molecular definition of chromosome translocations involving 10q24 and 19q13 in human malignant glioma cells. Cancer Genet. Cytogenet. 105, 60–68 (1998).
Kobe, B. & Deisenhofer, J. The leucine-rich repeat: a versatile binding motif. Trends Biochem. Sci. 19, 415–421 (1994).
Shoshan, Y. et al. Expression of oligodendrocyte progenitor cell antigens by gliomas: Implications for the histogenesis of brain tumors. Proc. Natl. Acad. Sci. USA 96, 10361–10366 (1999).
Jacobs, J.R. The midline glia of Drosophila: a molecular genetic model for the developmental function of glia. Prog. Neurobiol. 62, 475–508 (2000).
Brose, K. et al. Slit proteins bind robo receptors and have an evolutionary conserved role in repulsive axon guidance. Cell 96, 795–806 (1999).
Steck, P. et al. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nature Genet. 15, 356–362 (1997).
Groszer, M. et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 294, 2186–2189 (2001).
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Cowell, J. Epilepsy research gets new guidance. Nat Med 8, 219–220 (2002). https://doi.org/10.1038/nm0302-219
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DOI: https://doi.org/10.1038/nm0302-219
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