Detailed analysis of the dramatic T cell changes accompanying HIV disease point to homeostatic dysregulation as a primary cause of immunodeficiency (pages 208–214 and 215–221).
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References
Ho, D.D. et al. Rapid turnover of plasma virions and CD4 lymphocytes in HIV-1 infection. Nature 373, 123–126 (1995).
Wei, X. et al. Viral dynamics in human immunodeficiency virus type 1 infection. Nature 373, 117–122 (1995).
Pakker, N.G. et al. Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation. Nature Med. 4, 208–214 (1998).
Gorochov, G. et al. Perturbation of CD4 and CD8 T-cell repertoires during progression to AIDS and regulation of the CD4 repertoire during anti-viral therapy. Nature Med. 4, 215–221 (1998).
Roederer, M. et al. CD8 naive T cell counts decrease progressively in HIV-infected adults. J. Clin. Invest. 95, 2061–2066 (1995).
Roederer, M., De Rosa, S.C., Herzenberg, L.A. & Herzenberg, L.A. Immunology of T cells in AIDS: Dynamics revealed by eight-color flow cytometry. In Immune Modulating Agents (ed. Kresina, T.) 209–220 (Marcel Dekker, Inc., New York, 1998).
Woods, T.C., Roberts, B.D., Butera, S.T. & Folks, T.M. Loss of inducible virus in CD45RA naive cells after human immunodeficiency virus-1 entry accounts for preferential viral replication in CD45RO memory cells. Blood 29, 1635–1641 (1997).
Spina, C.A., Prince, H.E. & Richman, D.D. Preferential replication of HIV-1 in the CD45RO memory cell subset of primary CD4 lymphocytes in vitro J. Clin. Invest. 99, 1774–1785 (1997).
Roederer, M., Raju, P.A., Mitra, D.K., Herzenberg, L.A. & Herzenberg, L.A. HIV does not replicate in naive CD4 T cells stimulated with CD3/CD28. J. Clin. Invest. 99, 1555–1564 (1997).
Mosier, D. (Letter). Nature 375, 193–194 (1995).
Sprent, J. & Tough, D. (Letter). Nature 375, 194 (1995).
Connors, M. et al. HIV infection induces changes in CD4+ T-cell phenotype and depletions within the CD4+ T-cell repertoire that are not immediately restored by antiviral or immune-based therapies. Nature Med 3, 533–540 (1997).
Autran, B. et al. Positive effects of combined antiretroviral therapy on CD4+ T cell homeostasis and function in advanced HIV disease. Science 277, 112–116 (1997).
Rosenberg, Y.J. et al. variation in the CD4+ and CD8+ populations in lymph nodes does not reflect that in the blood during SIVMNE/E11S infection of macaques. J. Med. Primatol. 21, 131–137 (1992).
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Roederer, M. Getting to the HAART of T cell dynamics. Nat Med 4, 145–146 (1998). https://doi.org/10.1038/nm0298-145
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DOI: https://doi.org/10.1038/nm0298-145
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