Abstract
Inducing the formation of new blood vessels — a novel approach to treating myocardial ischemia
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Fidler, I.J. & Ellis, L.M. The implication of angiogenesis for the biology and therapy of cancer metastasis. Cell 79, 185–88 (1994).
Folkman, J. Angiogenesis in cancer, vascular, rheumatoid and other disease. Nature Med. 1, 27–31 (1995).
Risau, W. & Flamme, I., Ann. Rev. Cell. Dev. Biol. 11, 79–91 (1995).
Dvorak, H.F., Brown, L.F., Detmar, M. & Dvorak, A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability and angiogenesis. Am. J. Pathol. 146, 1029–1039 (1995).
Thomas, K.A. Vascular endothelial growth factor, a potent and selective angiogenic agent. J. Biol. Chem. 271, 603–606 (1996).
Olofsson, B. et al. Vascular endothelial growth factor B, a novel growth factor for endothelial Cells. Proc. Natl. Acad. Sci. U.S.A. 93, 2576–2581 (1996).
Joukov, V. et al. A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases. EMBO J. 15, 290–298 (1996).
Ferrara, N. et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene. Nature 380, 439–442 (1996).
Carmeliet, P. et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele. Nature 380, 435–439 (1996).
Slavin, J. Fibroblast growth factors: at the heart of angiogenesis. Cell. Biol. Int. 19, 431–444 (1995).
Folkman, J. & Shing, Y., Angiogenesis. J. Biol. Chem. 267, 10931–10934 (1992).
Kuwabara, K. et al. Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial Cells. Proc. Natl. Acad. Sci. U.S.A. 92, 4606–4610 (1995).
Shweiki, D., Itin, A., Softer, D. & Keshet, E. Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359, 843–845 (1992).
Tuder, R.M., Flook, B.E. & Voelkel, N.F. Increased gene expression for VEGF and the VEGF receptors KDR/Flk and Flt in lungs exposed to acute or to chronic hypoxia. Modulation of gene expression by nitric oxide. J. Clin. Invest. 95, 1798–1807 (1995).
Li, J. et al. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am. J. Physiol. 270, H1803–H1811 (1996).
Sellke, F.W. et al. Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium. Am. J. Physiol. 271, H713–H720 (1996).
Nomura, M. et al. Possible participation of autocrine and paracrine vascular endothelial growth factors in hypoxia-induced proliferation of endothelial Cells and pericytes. J. Biol. Chem. 270, 28316–28324 (1995).
Sasayama, S. & Fujita, M. Recent insights into coronary collateral circulation. Circulation 85, 1197–1204 (1992).
Simons, M. & Ware, J.A. Food for starving hearts. Nature Med. 2, 519–520 (1996).
Polverini, P.J. Cellular adhesion molecules. Am. J. Pathol. 148, 1023–1029 (1996).
Schaper, W. & Ito, W. Molecular mechanisms of collateral vessel growth. Circ. Res. 79, 911–919 (1996).
Hashimoto, E. et al. Rapid induction of vascular endothelial growth factor expression by transient ischemia in rat heart. Am. J. Physiol. 267, H1948–1954 (1994).
Li, J., Hampton, T., Morgam, J. & Simons, M., TGF-beta release increases VEGF expression in the heart. Circulation 94, 1–285 (1996).
Sharma, H.S. et al. Expression of angiogenic growth factors in the collateralized swine myocardium. Exs 61, 255–260 (1992).
More, J.W.I. & Sholley, M.M. Comparison of the neovascular effects of stimulated macrophages and neutrophils in autologous rabbit corneas. Am. J. Pathol. 120, 87–98 (1985).
Sunderkotter, C., Goebeler, M., Schulze-Osthoff, K., Bhardwaj, R., & Sorg, C., Macrophage-derived angiogenesis factors. Pharmacol. Ther. 51, 195–216 (1991).
Kuzuya, M. et al. Induction of angiogenesis by smooth muscle Cell-derived factor: possible role in neovascularization in atherosclerotic plaque. J. Cell Physiol. 164, 658–667 (1995).
Muhlhauser, J. et al. VEGF165 expressed by a replication-deficient recombinant adenovirus vector induces angiogenesis in vivo . Circulation Res. 77 1077–1086 (1995).
Mesri, E.A., Federoff, H.J. & Brownlee, M. Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice. Circulation Res. 76, 161–167 (1995).
Shen, H. et al. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood 81, 2767–2773 (1993).
Barleon, B. et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87, 3336–3343 (1996).
Edelman, E.R., Nugent, M.A., Smith, L.T. & Karnovsky, M.J. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J. Clin. Invest. 89, 465–473 (1992).
Cuevas, P., Gonzalez, A.M., Celler, F., & Baird, A., Vascular response to basic fibroblast growth factor when infused onto the normal adventitia or into the injured media of the rat carotid artery. Circulation Res. 69, 360–369 (1991).
Gordon, S., Fraser, I., Nath, D., Hughes, D. & Clarke, S. Macrophages in tissues and in vitro . Curr. Opin. Immunol. 4, 25–32 (1992).
Gordon, S., Clarke, S., Greaves, D. & Doyle, A. Molecular immunobiology of macrophages: recent progress. Curr. Opin. Immunol. 7, 24–33 (1995).
Arras, M., Ito, W., Winkler, B., Scholz, D. & Schaper, W. Enhancement of monocyte recruitment and activation by lipopolysaccharide leads to an increase of capillary sprouting in a rabbit model of hindlimb ischemia. (abstr.). Circulation 94, 1–608 (1996).
Westernacher, D. & Schaper, W. A novel heart derived inhibitor of vascular Cell proliferation. Purification and biological activity. J. Mol. Cell. Cardiol. 27, 1535–1543 (1995).
O'Reilly, M. et al. Angiostatin: A novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79, 315–328 (1994).
Yanagisawa-Miwa, A. et al. Salvage of infarcted myocardium by angiogenic action of basic fibroblast growth factor. Science 257, 1401–1403 (1992).
Battler, A. et al. Intracoronary injection of basic fibroblast growth factor enhances angiogenesis in infarcted swine myocardium. J. Am. Coll. Cardiol. 22, 2001–2006 (1993).
Padua, R.R., Sethi, R., Dhalla, N.S. & Kardami, E. Basic fibroblast growth factor is cardioprotective in ischemia-reperfusion injury. Mol. Cell. Biochem. 143, 129–135 (1995).
Sellke, F.W. et al. Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation. Am. J. Physiol. 267, H1303 1311 (1994).
Giordano, F.J. et al. Intracoronary transfer of fibroblast growth factor-5 increases blood flow and contractile function in an ischemic region of the heart. Nature Med. 2, 534–539 (1996).
Lazarous, D.F. et al. Effects of chronic systemic administration of basic fibroblast growth factor on collateral development in the canine heart. Circulation 91, 145–153 (1995).
Unger, E.F. et al. Basic fibroblast growth factor enhances myocardial collateral flow in a canine model. Am. J. Physiol. 266, H15881595 (1994).
Harada, K. et al. Basic fibroblast growth factor improves myocardial function in chronically ischemic porcine hearts. J. Clin. Invest. 94, 623–630 (1994).
Banai, S. et al. Effects of acidic fibroblast growth factor on normal and ischemic myocardium. Circulation Res. 69, 76–85 (1991).
Unger, E.F. et al. Extracardiac to coronary anastomoses support regional left ventricular function in dogs. Am. J. Physiol. 264, H1567–;1574 (1993).
Unger, E.F. et al. A model to assess interventions to improve collateral blood flow: continuous administration of agents into the left coronary artery in dogs. Cardiovasc. Res. 27, 785–791 (1993).
Lopez, J. et al. Perivascular delivery of prolonged half-life aFGF via EVAc results in angiographic collateral development, improvement in coronary flow and function in chronic myocardial ischemia. (abstr.) J. Am. Coll. Cardiol. 27, 30A (1996).
Banai, S. et al. Angiogenic-induced enhancement of collateral blood flow to ischemic myocardium by vascular endothelial growth factor in dogs. Circulation 89, 2183–2189 (1994).
Pearlman, J.D. et al. Magnetic resonance mapping demonstrates benefits of VEGF-induced myocardial angiogenesis. Nature Med. 1, 1085–1089 (1995).
Harada, K. et al. Vascular endothelial growth factor in chronic myocardial ischemia. Am. J. Physiol. 270, H1791H1802 (1996).
Baffour, R. et al. Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor. J. Vasc. Surg. 16, 181–191 (1992).
Takeshita, S. et al. Therapeutic angiogenesis. A single intra-arterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. J. Clin. Invest. 93, 662–670 (1994).
Isner, J.M. et al. Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb. Lancet 348, 370–374 (1996).
Schaper, W., De Brabander, M. & Lewi, P. DNA synthesis and mitoses in coronary collateral vessels of the dog. Circulation Res. 28, 671–679 (1971).
Takeshita, S. et al. Time course of increased Cellular proliferation in collateral arteries after administration of vascular endothelial growth factor in a rabbit model of lower limb vascular insufficiency. Am. J. Pathol. 147, 1649–1660 (1995).
Aiello, L.P. et al. Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders. N. Engl. J. Med. 331, 1480–1487 (1994).
Mazue, G., Bertolero, F., Jacob, C., Sarmientos, P. & Roncucci, R. Preclinical and clinical studies with recombinant human basic fibroblast growth factor. Ann. N. Y. Acad. Sci. 638, 329–340 (1991).
Lazarous, D.F. et al. Comparative effects of basic fibroblast growth factor and vascular endothelial growth factor on coronary collateral development and the arterial response to injury. Circulation 94, 1074–1082 (1996).
Cuevas, P. et al. Hypotensive activity of fibroblast growth factor. Science 254, 1208–1210 (1991).
Hariawala, M.D. et al. VEGF improves myocardial blood flow but produces EDRF-mediated hypotension in porcine hearts. J. Surg. Res. 63, 77–82 (1996).
Yang, W., Ando, J., Korenaga, R., Toyo-oka, T. & Kamiya, A. Exogenous nitric oxide inhibits proliferation of cultured vascular endothelial Cells. Biochem. Biophys. Res. Commun. 203, 1160–1167 (1994).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ware, J., Simons, M. Angiogenesis in ischemic heart disease. Nat Med 3, 158–164 (1997). https://doi.org/10.1038/nm0297-158
Issue Date:
DOI: https://doi.org/10.1038/nm0297-158
This article is cited by
-
Endothelial plasticity drives aberrant vascularization and impedes cardiac repair after myocardial infarction
Nature Cardiovascular Research (2022)
-
Therapeutic angiogenesis with exosomal microRNAs: an effectual approach for the treatment of myocardial ischemia
Heart Failure Reviews (2021)
-
Extracellular vesicles in diabetes mellitus induce alterations in endothelial cell morphology and migration
Journal of Translational Medicine (2020)
-
4-Hexylresorcinol and silk sericin increase the expression of vascular endothelial growth factor via different pathways
Scientific Reports (2019)
-
Regulation of angiogenesis by microRNAs in cardiovascular diseases
Angiogenesis (2018)