The α isoform of the IκB protein kinase has been identified as the missing link in a signaling pathway that controls mammary epithelial proliferation via the cell-cycle regulator cyclin D1. This new player may provide a promising target for inhibiting cyclin D1 expression, which is elevated in 50% of breast malignancies.
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Tonko-Geymayer, S., Doppler, W. An essential link to mammary cancer?. Nat Med 8, 108–110 (2002). https://doi.org/10.1038/nm0202-108
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DOI: https://doi.org/10.1038/nm0202-108
