Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A shot in the arm for cocaine addiction

Could immunization against cocaine be a viable prophylaxis for cocaine addiction?

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

References

  1. Committee to Study Medication Development and Research at the National Institute on Drug Abuse. Introduction in Development of Medications for the Treatment of Opiate and Cocaine Addictions: Issues for the Government and Private Sector. (eds Fulco, C.E., Liverman, C.T. & Earley, L.E.) 36–37 (National Academy Press, Washington, DC, 1995).

  2. Carrera, M.R.A. et al. Suppression of psychoactive effects of cocaine by active immunization. Nature. 378, 727–730 (1995).

    Article  CAS  Google Scholar 

  3. Christenson, J.G. Radioimmunoassay for Benzoyl Ecogonine. US Patent 4102979 (1975).

  4. Leute, R.K. & Bolz, G., Nitrogen Derivates of Benzoyl Ecogonine. US Patent 3888866 (1975).

  5. Mule, S.J., Jukofsky, D., Kogan, M., De Pace, A. & Verebey, K. Evaluation of the radioimmunoassay for benzoylecgonine (a cocaine metabolite) in human urine. Clin. Chem. 23, 796–801 (1977).

    CAS  PubMed  Google Scholar 

  6. Landry, D.W., Zhao, K., Yang, G.X-.Q., Glickman, M. & Georgidis, T.M. Antibody-catalyzed degradation of cocaine. Science. 259, 1899–1901 (1993).

    Article  CAS  Google Scholar 

  7. Bonese, K.F., Wainer, B.H., Fitch, F.W., Rothberg, R.M. & Schuster, C.R. Changes in heroin selfadministration by a rhesus monkey after morphine immunisation. Nature. 252, 20–27 (1974).

    Article  Google Scholar 

  8. Carroll, F.I., Lewin, A.H., Boja, J.W. & Kuhar, M.J. (Substituted phenyl) tropan-2-carboxyIic acid ester analogues of cocaine. in Drug Design for Neuroscience. (ed. Kozikowski, A.P.) 149–166 (Raven, New York, 1993).

    Google Scholar 

  9. Ritz, M.C., Lamb, R.J., Goldberg, S.R. & Kuhar, M.J. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science. 237, 1219–1221 (1987).

    Article  CAS  Google Scholar 

  10. Giros, B. et al. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter. Mol. Pharmacol. 42, 383–390 (1992).

    CAS  PubMed  Google Scholar 

  11. Vandenbergh, D.J., Perisco, A.M. & Uhl, G.R. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic tag I RFLPs. Mol. Brain Res. 15, 161–166 (1992).

    Article  CAS  Google Scholar 

  12. Kityama, S. et al. Dopamine transporter sitedirected mutations differentially alter substrate transport and cocaine binding. Proc. Natl. Acad. Sci. USA. 89, 7782–7785 (1992).

    Article  Google Scholar 

  13. Carroll, F.I., Lewin, A.H. & Biswas, J. Chemical approaches to the treatment of cocaine abuse. Pharm. News. 1, 11–17 (1994).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Slusher, B., Jackson, P. A shot in the arm for cocaine addiction. Nat Med 2, 26–27 (1996). https://doi.org/10.1038/nm0196-26

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nm0196-26

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing