Insulin resistance can be good for your health when it is caused by klotho, a hormone that prolongs life. A reduction in insulin-stimulated intracellular glucose availability may prevent intracellular lipid overload and lipotoxicity, a proposed mechanism of hte life-shortening metabolic syndrome.
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Unger, R. Klotho-induced insulin resistance: a blessing in disguise?. Nat Med 12, 56–57 (2006). https://doi.org/10.1038/nm0106-56
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DOI: https://doi.org/10.1038/nm0106-56
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