Abstract
The orphan nuclear receptor, Dax1, was originally proposed to act as an 'anti-testis' factor. We find, however, that Nr0b1 (also called Dax1 and Ahch, which encodes Dax1) is in fact required for testis differentiation.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Sinclair, A.H. et al. Nature 346, 240–244 (1990).
Bardoni, B. et al. Nat. Genet. 7, 497–501 (1994).
Muscatelli, F. et al. Nature 372, 672–676 (1994).
Swain, A., Narvaez, V., Burgoyne, P., Camerino, G. & Lovell-Badge, R. Nature 391, 761–767 (1998).
Yu, R.N., Ito, M., Saunders, T.L., Camper, S.A. & Jameson, J.L. Nat. Genet. 20, 353–357 (1998).
Eicher, E.M., Washburn, L.L., Whitney, J.B. 3rd & Morrow, K.E. Science 217, 535–537 (1982).
Eicher, E.M. et al. Nat. Genet. 14, 206–209 (1996).
Valerie, V.P.I., Chaboissier, M.C., Rooij, D.G.D. & Schedl, A. Nat. Genet. 28, 216–217 (2001).
Meeks, J.J. et al. Development 130, 1029–1036 (2003).
Ito, M., Yu, R. & Jameson, J.L. Mol. Cell. Biol. 17, 1476–1483 (1997).
Tevosian, S.G. et al. Development 129, 4627–4634 (2002).
Acknowledgements
This work was supported by grants from the US National Institutes of Health.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Meeks, J., Weiss, J. & Jameson, J. Dax1 is required for testis determination. Nat Genet 34, 32–33 (2003). https://doi.org/10.1038/ng1141
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/ng1141
This article is cited by
-
Live Birth in Sex-Reversed XY Mice Lacking the Nuclear Receptor Dax1
Scientific Reports (2020)
-
Molecular cytogenetic analysis and genetic counseling: a case report of eight 46,XX males and a literature review
Molecular Cytogenetics (2019)
-
Differentiation roadmap of embryonic Sertoli cells derived from mouse embryonic stem cells
Stem Cell Research & Therapy (2019)
-
Integrative epigenomic analysis reveals unique epigenetic signatures involved in unipotency of mouse female germline stem cells
Genome Biology (2016)
-
Co-expression analysis and identification of fecundity-related long non-coding RNAs in sheep ovaries
Scientific Reports (2016)