An endosomal ferric reductase has long been implicated in the transferrin cycle. Identification of the gene mutated in a genetic anemia in mice uncovers a new family of ferric reductase enzymes involved in reduction of transferrin-bound iron.
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McKie, A. A ferrireductase fills the gap in the transferrin cycle. Nat Genet 37, 1159–1160 (2005). https://doi.org/10.1038/ng1105-1159
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DOI: https://doi.org/10.1038/ng1105-1159
