A deletion that removes 1.6 Mb of DNA and several genes from the Y chromosome increases its carriers' chance of infertility, yet is present in ∼2% of men. The Y chromosome can no longer be regarded as a neutral locus in evolutionary studies.
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Tyler-Smith, C., McVean, G. The comings and goings of a Y polymorphism. Nat Genet 35, 201–202 (2003). https://doi.org/10.1038/ng1103-201
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DOI: https://doi.org/10.1038/ng1103-201
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