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Ciliary signaling goes down the tubes

Nature Genetics volume 33, pages 113–114 (2003)Cite this article

The focus of research on polycystic kidney disease (PKD) has recently shifted to the primary cilia of renal epithelial cells. A new study shows that the protein products of the genes mutated in PKD mediate mechanosensory calcium mobilization, suggesting that a disruption of fluid-flow sensing triggers abnormal cell proliferation and cyst growth.

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Figure 1: End-stage human autosomal dominant polycystic kidney (right) compared with a normal kidney (left).
Figure 2: Scanning electron micrograph of the inside of a collecting-duct cyst from a human autosomal dominant polycystic kidney.

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  1. Department of Biochemistry and Molecular Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA

    James P. Calvet

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  1. James P. Calvet
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Calvet, J. Ciliary signaling goes down the tubes. Nat Genet 33, 113–114 (2003). https://doi.org/10.1038/ng1078

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