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FANCL, as in ligase

Biochemical purification has identified a new component of the Fanconi anemia complex. The protein has ubiquitin ligase activity and may be the long-sought enzyme responsible for monoubiquitination of FANCD2.

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Figure 1: Model of Fanconi anemia pathway.

Katie Ris

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Grompe, M. FANCL, as in ligase. Nat Genet 35, 113–114 (2003). https://doi.org/10.1038/ng1003-113

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