Biochemical purification has identified a new component of the Fanconi anemia complex. The protein has ubiquitin ligase activity and may be the long-sought enzyme responsible for monoubiquitination of FANCD2.
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References
Auerbach, A.D., Buchwald, M. & Joenje, H. Fanconi Anemia. in The Metabolic and Molecular Basis of Inherited Disease (eds. Scriver, C.R., Beaudet, A.L., Sly, W.S. & Valle, D.) 753–783 (McGraw-Hill, New York, 2001).
D'Andrea, A.D. & Grompe, M. Nat. Rev. Cancer 3, 23–34 (2003).
Garcia-Higuera, I. et al. Mol. Cell 7, 249–262 (2001).
Howlett, N.G. et al. Science 297, 606–609 (2002).
Meetei, A.R. et al. Nat. Genet. 35, 165–170 (2003).
Fanconi, G. Semin. Hematol. 4, 233–240 (1967).
Yamamoto, K. et al. Mol. Cell. Biol. 23, 5421–5230 (2003).
Garcia-Higuera, I., Kuang, Y., Naf, D., Wasik, J. & D'Andrea, A.D. Mol. Cell. Biol. 19, 4866–4873 (1999).
Taniguchi, T. et al. Blood 100, 2414–2420 (2002).
Vandenberg, C.J. et al. Mol. Cell 12, 247–254 (2003).
Meetei, A.R. et al. Mol. Cell. Biol. 23, 3417–3426 (2003).
Coscoy, L. & Ganem, D. Trends Cell Biol. 13, 7–12 (2003).
Bruun, D. et al. DNA Repair advance online publication, 18 September 2003 (doi:10.1016/51568-7864 (03) 00112-5.
van der Heijden, M.S., Yeo, C.J., Hruban, R.H. & Kern, S.E. Cancer Res. 63, 2585–2588 (2003).
Taniguchi, T. et al. Nat. Med. 9, 568–574 (2003).
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Grompe, M. FANCL, as in ligase. Nat Genet 35, 113–114 (2003). https://doi.org/10.1038/ng1003-113
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DOI: https://doi.org/10.1038/ng1003-113
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Involvement of FANCD2 in Energy Metabolism via ATP5α
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