Positional cloning of common disease genes is a central but elusive goal of human geneticists. Progress is now reported by Bell and colleagues in their study of NIDDM1, a locus implicated in type 2 diabetes. The complex nature of the reported association illustrates the challenge of implicating a specific gene and mutation in the causation of polygenic disease.
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Altshuler, D., Daly, M. & Kruglyak, L. Guilt by association. Nat Genet 26, 135–137 (2000). https://doi.org/10.1038/79839
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DOI: https://doi.org/10.1038/79839
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