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The genomics gamble

Pair-wise genome comparisons offer new sources of information about the patterns and processes that influence genomic designs. Replication-dependent rearrangements, as indicated by the symmetric gene organization pattern in the genomes of Chlamydia pneumoniae and Chlamydia trachomatis, may provide a missing link in the reconstruction of historical events from modern genomes.

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Andersson, S. The genomics gamble. Nat Genet 26, 134–135 (2000). https://doi.org/10.1038/79835

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