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The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse

Nature Genetics volume 1, pages 333–336 (1992)Cite this article

Abstract

The gene encoding the granulocyte macrophage colony stimulating factor receptor α subunit (CSF2RA) has previously been mapped to the pseudoautosomal region of the human sex chromosomes. In contrast, we report that the murine locus, Csf2ra, maps to an autosome in the laboratory mouse. By in situ hybridization and genetic mapping, Csf2ra maps at telomeric band D2 of mouse chromosome 19. This first instance of a pseudoautosomal locus in human being autosomal in mouse, indicates incomplete conservation between the human and mouse X chromosomes and suggests that the genetic content of the pseudoautosomal region may differ between species of eutherian mammals due to chromosomal rearrangements.

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Author notes

  1. Daniel F. Schorderet

    Present address: Division of Medical Genetics, CHUV, 1011, Lausanne, Switzerland

Authors and Affiliations

  1. Department of Pathology, University of Washington, Seattle, Washington, 98195, USA

    Christine M. Disteche & David A. Adler

  2. Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, ABL-Basic Research Program, Frederick, Maryland, 21702, USA

    Camilynn I. Brannan, Neal G. Copeland & Nancy A. Jenkins

  3. Immunex Corporation, Seattle, Washington, 98101, USA

    Alf Larsen, David Gearing & Linda S. Park

  4. Department of Genetics, University of Washington, Seattle, Washington, 98195, USA

    Daniel F. Schorderet

Authors
  1. Christine M. Disteche
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  2. Camilynn I. Brannan
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  3. Alf Larsen
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  4. David A. Adler
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  5. Daniel F. Schorderet
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  6. David Gearing
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  9. Linda S. Park
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Disteche, C., Brannan, C., Larsen, A. et al. The human pseudoautosomal GM–CSF receptor α subunit gene is autosomal in mouse. Nat Genet 1, 333–336 (1992). https://doi.org/10.1038/ng0892-333

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  • DOI: https://doi.org/10.1038/ng0892-333

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