An earlier report of high-frequency ESR1 amplification in breast cancer is now challenged by correspondence from four groups. This discussion of whether or not there is something 'FISHy' about ESR1 amplification highlights the difficulty of validating such observations, leaving the frequency and clinical significance of ESR1 amplification in breast cancer an open question.
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Albertson, D. Conflicting evidence on the frequency of ESR1 amplification in breast cancer. Nat Genet 40, 821–822 (2008). https://doi.org/10.1038/ng0708-821
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DOI: https://doi.org/10.1038/ng0708-821
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